Studying Swallowing Function in Healthy Individuals and Those with Dysphagia
This study is looking at how swallowing muscles work in healthy people and those with difficulty swallowing (dysphagia). Researchers want to understand if the way your throat moves during swallowing affects how food or liquid travels down your esophagus (the tube connecting your throat to your stomach). They will use a special device worn around the neck to gently adjust throat movement, along with imaging and pressure measurements. The study aims to see if this device, used for six weeks as an exercise, can improve swallowing function. Success will be measured by changes in pressure waves in your throat during swallowing. You can join if you are 18 to 90 years old and are either healthy or have dysphagia with normal esophageal test results. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 557 participants. It involves using a device to modulate throat movement and another device for a six-week exercise regimen.
- What's involved
- You would undergo concurrent manometry/impedance (pressure and flow measurements) and fluoroscopy (X-ray imaging) with and without a laryngeal restriction device. Some participants will also use a swallow muscle exercising device for six weeks, with measurements taken before and after this period.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements are taken before and after a six-week exercise regimen, and during deglutitive restriction of the larynx (throat movement). The duration of follow-up after these measurements is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Striated Esophageal Motor Function Modulation in Health and Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Reza Shaker · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- peak deglutitive pharyngeal peristaltic wave pressureBefore six weeks exerciser regimen, during deglutitive restriction of the larynx
Peak deglutitive pharyngeal peristaltic wave pressure will be measured at positions 2-8cm above the upper margin of the manometrically determined upper esophageal sphincter high-pressure zone (UESHPZ)
- peak deglutitive pharyngeal peristaltic wave pressureAfter six weeks exerciser regimen, during deglutitive restriction of the larynx
Peak deglutitive pharyngeal peristaltic wave pressure will be measured at positions 2-8cm above the upper margin of the manometrically determined upper esophageal sphincter high-pressure zone (UESHPZ)
- hypopharyngeal intra-bolusBefore exerciser regimen, during deglutitive restriction of the larynx
pressure within the swallowed bolus as it passes through the hypopharynx
- hypopharyngeal intra-bolusAfter exerciser regimen, during deglutitive restriction of the larynx
pressure within the swallowed bolus as it passes through the hypopharynx
- upper esophageal sphincter (UES) nadir pressureBefore six weeks exerciser regimen, during deglutitive restriction of the larynx
minimum pressure during deglutitive UES relaxation
- upper esophageal sphincter (UES) nadir pressureAfter six weeks exerciser regimen, during deglutitive restriction of the larynx
minimum pressure during deglutitive UES relaxation
- pharyngeal contractile integralBefore six weeks exerciser regimen, during deglutitive restriction of the larynx
Time-space integral of the pharynx during swallows as measured from the manometric display
- pharyngeal contractile integralAfter six weeks exerciser regimen, during deglutitive restriction of the larynx
Time-space integral of the pharynx during swallows as measured from the manometric display
- maximum excursion of the hyo-laryngeal complexBefore six weeks exerciser regimen, during deglutitive restriction of the larynx
maximum deglutitive excursion of the hyoid and larynx from the pre-swallow resting position as measured from fluoroscopic images
- maximum excursion of the hyo-laryngeal complexAfter six weeks exerciser regimen, during deglutitive restriction of the larynx
maximum deglutitive excursion of the hyoid and larynx from the pre-swallow resting position as measured from fluoroscopic images
- UES anterior-posterior maximum diameter during swallowsBefore six weeks exerciser regimen, during deglutitive restriction of the larynx
maximum deglutitive diameter in the anterior-posterior direction of the UES measured from fluoroscopic images
- UES anterior-posterior maximum diameter during swallowsAfter six weeks exerciser regimen, during deglutitive restriction of the larynx
maximum deglutitive diameter in the anterior-posterior direction of the UES measured from fluoroscopic images