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UPURS Trial for Symptomatic Obstructing Ureteral Stones

This study is looking at the best way to manage painful kidney stones (ureteral stones) that are blocking the urinary tract. It compares two common approaches: immediate surgery (upfront ureteroscopy) versus watching and waiting for the stone to pass naturally (observation and delayed intervention). Researchers want to see which approach leads to less pain and anxiety for patients after 3 months. You might be able to join if you are an adult, come to the emergency room with a kidney stone 5mm or larger, and have symptoms like pain, nausea, vomiting, or blood in your urine. The study aims to enroll 100 participants.

Study design
This is a randomized controlled trial, meaning participants will be randomly assigned to one of two groups. It is not blinded, so both you and your doctors will know which treatment you are receiving. The study plans to enroll 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain and anxiety will be measured at 3 months after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05715086

UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

Recruiting
NAAges 18+InterventionalTreatment
University of California, San Francisco
~100 participants
Updated 2025-01-17 on ClinicalTrials.gov
What's tested:Ureteroscopy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain Score
Measured over 3 months
+1 more outcome measured

Conditions

Ureteral Stone

Explore related trials

Ureterolithiasis

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Thomas Chi, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Catherine Arevalo, BA
[email protected]
415-514-0918
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Presenting to the Emergency Department (ED)
Adult (\> 18 yo)
≥5mm ureteral stone diagnosed on CT scan
Presence of symptoms (pain, nausea, vomiting, hematuria)

Exclusion

Strict indication for stent
Stone burden not amenable to Ureteroscopy (URS)
Dirty urine analysis (UA) or positive urine culture (UCx)
Transplant kidney
Presence of conduit
Comorbidities not optimized for surgery
Strong preference for surgery or observation

What this trial measures

  • Pain Score3 months

    Measure on a scale of 1-10, with zero indicating no pain and 10 indicating the worst pain.

  • Anxiety Score3 months

    Measure on a scale of 1-10, the score ranges from 0-10, with zero indicating no anxiety and 10 indicating the worst anxiety.