Metabolic Effects of Intermittent Fasting Study

This study is looking at how intermittent fasting affects your body's metabolism, especially if you are at high risk for diabetes. Researchers want to see if the benefits of fasting, like changes in fat levels and bone health, happen even if you don't lose weight. You might be able to join if you are between 21 and 45 years old, have a BMI (Body Mass Index) between 21 and 29, have normal thyroid function, and have a close relative with type 2 diabetes or a history of gestational diabetes. The study will measure changes in fat content and bone structure over three months to understand these effects. The current status of this study is unclear, and it plans to enroll 90 participants.

Study design
This is an interventional study planning to enroll 90 participants. It compares a fasting group to a group focused on maintaining their current weight.
What's involved
Participants will either fast one day per week for 12 weeks or receive counseling to maintain their body weight and on optimal diet and activity. Measurements will be taken at the beginning of the study and after 3 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months, with measurements taken at baseline and at the 3-month mark.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05722873

The Metabolic Effects of Intermittent Fasting

Recruiting
NAAges 21–45InterventionalPrevention
University of Pittsburgh
~90 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Fasting armWeight maintenanceCounseling

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Triglyceride carbon content and degree of saturation
Measured over Baseline, 3 months
+1 more outcome measured
Normal and Overweight Individuals at High-risk of Diabetes
1 sites across 1 states
Pennsylvania1
  • Pouneh Fazeli, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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  • Triglyceride carbon content and degree of saturationBaseline, 3 months

    Change in triglyceride carbon content and degree of saturation (% variation explained by both carbon number and double bond number in a regression model) between Baseline and Final Intervention visits

  • Trabecular bone microarchitectureBaseline, 3 months

    Change in trabecular bone volume fraction at the radius between Baseline and Final Intervention visits