Studying Breathing in Heart Failure with Preserved Ejection Fraction (HFpEF) and Obesity
This study is looking at how breathing limitations affect shortness of breath (dyspnea on exertion or DOE) and exercise ability in people with a type of heart failure called HFpEF (Heart Failure with Preserved Ejection Fraction) and obesity. Researchers believe that obesity plays a big role in these breathing problems. You might be eligible if you are 55 to 90 years old, have signs of heart failure, and specific heart function measurements (ejection fraction > 0.50, NT-proBNP > 300 ng/dl). The study will compare breathing a special helium-oxygen gas mixture (HeO2) to normal room air to see if it improves breathing and exercise capacity. The study aims to enroll 78 participants, but its current status is unclear.
- Study design
- This interventional study plans to enroll 78 participants. It will compare breathing a helium-oxygen gas mixture (HeO2) to normal room air.
- What's involved
- You would undergo clinical screening tests, including exercise tests, lung function tests, and body composition scans. You would also breathe different gas mixtures for measurements over a few days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements for primary outcomes will be taken at Day 2, and Day 3 or 4.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
At a glance
Conditions
NCT05723679
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UT Southwestern Medical Center
Dallas, Texasstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Tony G Babb, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center
- Bryce N Balmain, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center
Who to contact
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Inclusion
Exclusion
What this trial measures
- O2 cost of breathing (Objective 1)Day 2
O2 cost of breathing measured during eucapnic voluntary hyperventilation, and calculated using oxygen uptake and ventilation variables.
- Change in DOE during HeO2 breathing (Objective 2)Day 3 or 4
Dyspnea on Exertion (DOE) will be assessed via ratings of perceived breathlessness (RPB) using a 0-10 Borg Scale, and will be compared with that measured during room air breathing.
- Change in peak exercise capacity during HeO2 breathing (Objective 2)Day 3 or 4
Peak exercise capacity will be assessed by measuring peak oxygen uptake (in L/min, measured via a breath-by-breath metabolic measurement system), peak power output recorded from a cycle ergometer (Watts), and/or total exercise duration (minutes).