Empagliflozin for Cirrhosis and Ascites

This study is looking at how a medication called empagliflozin (10 mg) affects people with cirrhosis (severe liver scarring) and ascites (fluid buildup in the belly). Researchers want to see if empagliflozin can help your body get rid of extra salt and water. You would receive either empagliflozin or a placebo (an inactive pill) for 14 days, then have a break, and then switch to the other treatment for another 14 days. To join, you need to be at least 18 years old, have cirrhosis with ascites, be on stable diuretic (water pill) medication, and have a kidney function test (eGFR) of 30 or higher. The study is currently unclear on its recruitment status and plans to enroll 20 participants.

Study design
This is a randomized study where participants receive empagliflozin or a placebo, then switch treatments. It involves 20 participants.
What's involved
Participants will take either empagliflozin or a placebo for 14 days, have a 14-day break, and then take the other treatment for 14 days.
Compensation
Not stated in the trial record.
Follow-up
The main effects are measured after 14 days of each treatment period.

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NCT05726032

Empagliflozin in Patients With Cirrhosis and Ascites

Recruiting
PHASE2Ages 18+Interventional
Yale University
~20 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:Empagliflozin 10 MGMatching Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in FENa with administration of study drug (10 mg empagliflozin vs. identical placebo)
Measured over 14 days
+1 more outcome measured
Cirrhosis
Liver Failure
1 sites across 1 states
Connecticut1
  • Jeffrey Testani, MD · PRINCIPAL_INVESTIGATOR · Yale University

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  • Change in FENa with administration of study drug (10 mg empagliflozin vs. identical placebo)14 days

    Change in fractional excretion of sodium with administration of study drug (10 mg empagliflozin vs. identical placebo)

  • Change in total body water (TBW) before and after a 14-day course of study drug14 days

    Change in total body water (TBW) before and after a 14-day course of study drug (10 mg/day empagliflozin vs. identical placebo)