Ocular Blood Flow Imaging for Glaucoma Assessment

This study is looking at a new way to assess glaucoma using a special imaging device called XyCAM RI and XyCAM FC. Researchers want to see if this device can measure blood flow in your eyes to tell the difference between healthy eyes and eyes with early-stage glaucoma. They also want to confirm that the XyCAM FC can take both regular pictures of your eye and measure blood flow at the same time. You might be able to join if you are 18 to 88 years old, have healthy vision, are being checked for glaucoma, or have moderate to severe glaucoma. The study involves imaging your eyes and inhaling 100% oxygen during some imaging. The main goal is to measure blood flow velocity in your eyes over about one year.

Study design
This is an interventional study planning to enroll 150 participants. It is not specified if it is randomized or blinded.
What's involved
You will have your blood pressure, heart rate, height, and weight measured, and your pupils will be dilated with eye drops (tropicamide). You will undergo several eye imaging tests, including some while inhaling 100% oxygen. The imaging sessions will take about 80 minutes, with an additional 60 minutes for other procedures.
Compensation
Not stated in the trial record.
Follow-up
Blood flow velocity will be measured through study completion, which is an average of 1 year.

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NCT05726058

Ocular Blood Flow Imaging for Glaucoma Assessment

Recruiting
NAAges 18–88InterventionalDiagnostic
University of Maryland, Baltimore
~150 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:XyCAM with oxygen

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood flow velocity measure
Measured over through study completion, an average of 1 year
Glaucoma
1 sites across 1 states
Maryland1
  • Grace Forbes, MS · STUDY_DIRECTOR · University of Maryland, Baltimore

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Eligibility criteria

Inclusion

Age 18 and older with binocular vision
Able to provide informed consent
Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria

Exclusion

The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
The subject has prior ocular disease other than glaucoma
The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
The subject has more than 15 diopters of refractive error
The subject is a female who is pregnant or nursing
The subject has diabetes mellitus
  • Blood flow velocity measurethrough study completion, an average of 1 year

    Dynamic video of ocular blood flow