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Quality of Life and Muscle Loss in Patients with Ascites

This study is looking at how quality of life and sarcopenia (muscle loss) change over time in people with ascites (fluid buildup in the belly) due to liver disease or cancer. We want to understand how ascites affects your daily life and how your muscles change. You might be able to join if you are 18 or older, have ascites that needs frequent draining, and are generally well enough to participate. We will measure your quality of life using surveys and assess muscle loss from CT scans over six months. This will help us better understand and care for people with ascites.

Study design
This is an observational study planning to enroll 70 participants. It means researchers will watch and collect information without giving any specific treatments.
What's involved
You would complete quality of life surveys at the start, then at 1, 2, 4, and 6 months. Muscle measurements from a CT scan will be taken at the start, 2, and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months to measure changes in quality of life and sarcopenia.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05726747

QOL and Sarcopenia in Patients With Ascites

Recruiting
Not specifiedAges 18+Observational
Abramson Cancer Center at Penn Medicine
~70 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:Quality of Life surveys

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Health-Related Quality of Life scores as measured by the PROMIS-10 questionnaire
Measured over 6 months
+1 more outcome measured

Conditions

Ascites Hepatic
Ascites, Malignant

Explore related trials

Malignant Peritoneal EffusionPeritoneal EffusionSarcopenia

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Michael Soulen, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Michael C Soulen, MD
[email protected]
2154218647
Email the study team

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What this trial measures

  • Health-Related Quality of Life scores as measured by the PROMIS-10 questionnaire6 months

    Patient-Reported Outcomes Measurement Information System (PROMIS-10) survey scores physical and mental health on a 4-20 point scale which are combined into an overall score with higher scores reflecting better quality of life.

  • Sarcopenia as measured by psoas, paraspinal, and total abdominal wall muscle areas6 months

    assessed by a limited CT scan of the abdomen at the level of L4. Cross-sectional muscle area is measured.