vGRID SBRT for Unresectable or Metastatic Liver Cancer

This study is testing a new way to deliver radiation therapy called vGRID SBRT (Stereotactic Body Radiation Treatment) for people with liver cancer (hepatocellular carcinoma or mixed HCC and cholangiocarcinoma) that cannot be removed by surgery or has spread. The goal is to find the highest safe dose of this radiation treatment. You may be able to join if you are 18 or older, have a good performance status (meaning you can perform daily activities), and have confirmed liver cancer. The study will look at how well people tolerate the treatment and any side effects. The current status of the study is unclear, and it plans to enroll 18 participants.

Study design
This is an interventional study with a planned enrollment of 18 participants. It is designed to find the maximum tolerated dose of a single radiation treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, maximum tolerated dose, is measured from the first day after treatment through 3 months post-radiation.

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NCT05727787

vGRID SBRT: A Phase I Clinical Trial in Unresectable or Metastatic HCC

Recruiting
NAAges 18+InterventionalTreatment
University of Kansas Medical Center
~18 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:Stereotactic Body Radiation Treatment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximum tolerated dose (MTD) of Single Fraction GRID SBRT
Measured over First day of post-GRID SBRT through 3 month post-radiation
Liver Cancer
1 sites across 1 states
Kansas1
  • David Akhavan, MD · PRINCIPAL_INVESTIGATOR · University of Kansas Medical Center

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  • Maximum tolerated dose (MTD) of Single Fraction GRID SBRTFirst day of post-GRID SBRT through 3 month post-radiation

    Safely identify MTD of Single Fraction GRID SBRT and CTCAE v5.0 related toxicity: Irreversible grade 3 hepatotoxicity, grade 4 or 5 hepatotoxicity, grade 4 or 5 gastrointestinal toxicity.