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VIEWS-2 Study for Stroke Recovery

This study, called VIEWS-2, is looking at how different types of physical therapy can help people recover walking ability after a stroke. Researchers want to understand if focusing on walking specifically, and how hard you exercise (intensity), affects how well you recover. You might receive up to 30 one-hour sessions of physical therapy. Some sessions will focus only on walking, while others will include varied exercises. Some groups will exercise at a higher intensity, and others at a lower intensity. The study is for adults aged 18-85 who had a stroke 1-6 months ago and have some weakness on one side of their body (hemiparesis). To see if the treatments are successful, researchers will measure changes in your walking ability using a 6-minute walk test after about 8-10 weeks. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 100 participants. It compares different types and intensities of physical therapy.
What's involved
You would participate in up to 30 one-hour physical therapy sessions. Your walking ability will be measured after approximately 8-10 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at approximately 8-10 weeks after the start of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05727930

Variable Intensive Early Walking Post-Stroke - 2 (VIEWS-2)

Recruiting
NAAges 18–85InterventionalTreatment
Indiana University
~100 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:High-intensity, task-specific (i.e., walking) interventionsHigh-intensity, non-specific physical therapy interventionsLow-intensity, task-specific physical therapy interventionsLow-intensity, non-specific physical therapy interventions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in 6 minute walk test
Measured over Approximately 8-10 weeks

Conditions

Stroke

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Stroke

NCT05727930

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Rehabilitation Hospital of Indiana

    Indianapolis, Indianastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • George Hornby · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

George Hornby
[email protected]
317-329-2353
Email the study team

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Eligibility criteria

Inclusion

Sub-acute stroke (1-6 months)
Hemiparesis (Fugl-Meyer \<34) without cerebellar deficits
Ability to ambulate with or without physical assistance over 10 meters but \< 1.0 m/s and assistive devices and below-knee bracing is allowed.
Ability to sit \> 30 seconds without upper-extremity support or physical assistance
Ability to follow 3-step commands
Provision of informed consent and medical clearance from a supervising physician or medical provider to participate
Must have the ability to consent or have a legal health care power of attorney or legally authorized representative to consent for participation on their behalf

Exclusion

Significant cardiovascular, metabolic, or respiratory disease that limits exercise participation (e.g. previous myocardial infarction \< 3 months prior, uncompensated congestive heart failure, resting blood pressure \> 210/110 mmHg, uncontrolled diabetes, end-stage renal disease, severe infectious or psychiatry disease, or advanced malignancy)
If during the graded-treadmill exercise evaluation, the participant presents with absolute criteria for termination of exercise testing during initial testing (e.g. moderate to severe angina, ST elevation \> 1.0mm without preexisting Q wave secondary to prior MI, signs of poor perfusion, etc).
Any orthopedic or neurological disorders that limited walking to \<50m prior to stroke onset.
Cannot receive physical therapy once baseline testing begins
If patients are prescribed botulinum toxin for their lower extremities will be excluded only if the dosage for any specific muscle is \>50 units in leg muscles above the knee. If doses are \> than 50 units in leg muscles below the knee, the participant will use an ankle-foot orthosis to minimze contributions of those mscles to locomotor function.

What this trial measures

  • Changes in 6 minute walk testApproximately 8-10 weeks

    Changes in 6 min walk test from baseline to post-training