Cannabis and Opioid Use Disorder Study

This study is looking at how inhaled vaporized cannabis affects people with opioid use disorder (OUD). Researchers want to see if cannabis can help with opioid withdrawal symptoms. You might be able to join if you are between 18 and 55 years old and have opioid use disorder, but are not currently seeking treatment for it. You cannot join if you have other medical conditions that need ongoing medical care. The study will compare cannabis to a placebo (an inactive substance) and also look at the effects of an intranasal opioid. The main goal is to measure changes in opioid withdrawal severity using a Visual Analog Scale (VAS), which is a way to rate your symptoms. There are plans to include 15 participants, but the current status of the study is unclear.

Study design
This is an interventional study that plans to enroll 15 participants. It uses a double-blind approach, meaning neither you nor the study staff will know if you are receiving cannabis, a placebo, or an intranasal opioid.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, opioid withdrawal severity, is measured as a change from baseline, but the duration of follow-up is not specified.

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NCT05729932

Cannabis and Opioid Use Disorder

Recruiting
PHASE1Ages 18–55InterventionalBasic science
Shanna Babalonis, PhD
~15 participants
Updated 2026-06-18 on ClinicalTrials.gov
What's tested:Inhaled vaporized cannabisIntransal opioid

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline - Opioid Withdrawal Severity - Visual Analog Scale (VAS)
Measured over Change from baseline
Opioid Use Disorder
1 sites across 1 states
Kentucky1
  • Shanna Babalonis, PhD · PRINCIPAL_INVESTIGATOR · University of Kentucky

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Eligibility criteria

Inclusion

Current opioid use disorder

Exclusion

Current medical conditions that require medical management
  • Change from Baseline - Opioid Withdrawal Severity - Visual Analog Scale (VAS)Change from baseline

    Subjective ratings of opioid withdrawal severity on visual analog scale (scale 0-100; 0 = not at all, 100 = extremely)