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Validating Blood Biomarkers for Gulf War Illness

This observational study is looking for ways to better understand Gulf War Illness (GWI). Researchers are studying blood samples from veterans to find specific markers (biomarkers) that might be linked to GWI and its effects on the brain. They want to identify patterns in blood fats (lipids) and other substances that could explain cognitive decline and energy problems often seen in GWI. The study will also explore how diet, medical history, and other biological factors might influence these blood markers. This research aims to validate these blood markers to help with diagnosis and understanding GWI. The study plans to enroll 100 participants, including veterans aged 35 or older who meet the criteria for GWI, and control veterans in the same age range.

Study design
This is an observational study planning to enroll 100 participants. It is not testing a new treatment but rather observing and collecting information.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, including validating blood biomarkers and identifying blood/lipid profiles, will be measured between 2022 and 2024.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05736146

Validating Gulf War Illness Blood Biomarkers

Recruiting
Not specifiedAges 35+Observational
Roskamp Institute Inc.
~100 participants
Updated 2025-07-24 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Validate Blood Biomarkers
Measured over 2022-2024
+3 more outcomes measured

Conditions

Gulf War Syndrome
Gulf War Illness

Explore related trials

Gulf war syndrome

NCT05736146

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Boston University

    Boston, Massachusettsstudy coordinator listed

    Recruiting

  • Palto Alto Veterans Institute for Research

    Palo Alto, Californiastudy coordinator listed

    Recruiting

  • The Roskamp Institute

    Sarasota, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Laila Abdullah, Ph.D. · PRINCIPAL_INVESTIGATOR · The Roskamp Institute
  • Michael Hoffmann, MD · PRINCIPAL_INVESTIGATOR · The Roskamp Institute
  • Kim Sullivan, Ph.D · PRINCIPAL_INVESTIGATOR · Boston University
  • Maheen Adamson, Ph.D. · PRINCIPAL_INVESTIGATOR · Palo Alto Veterans Institute of Research

Who to contact

Dakota Helgager, B.S
[email protected]
(941) - 256 - 8019 · ext. 3008
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

What this trial measures

  • Validate Blood Biomarkers2022-2024

    To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

  • Identify Blood/Lipid Profiles2022-2024

    To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI.

  • Effect of Dietary, Medical and Biological Factors2022-2024

    To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans.

  • Metabolites Correlating with Cognitive Decline2022-2024

    To identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI.