Validating a New Algorithm for Energy Expenditure in Movement Disorders
This observational study aims to check how accurately a new computer program (machine-learned accelerometer algorithm) can estimate the total daily energy your body uses (Total Daily Energy Expenditure or TDEE). This new program is designed for people with movement difficulties, as current programs aren't very accurate for them. You would receive a special drink called Doubly-Labeled Water, which helps measure your energy use. Researchers will compare the energy estimates from the new program with measurements from the Doubly-Labeled Water. The study is looking for about 125 adults who can walk on their own, speak English, and have a smartphone and internet access. The goal is to create a better tool for future research on physical activity for people with movement limitations. The current recruitment status is unclear.
- Study design
- This is an observational study involving approximately 125 adult participants. It is not a randomized or blinded study.
- What's involved
- You would attend three study visits. These visits include physical function tests, a body composition scan (DXA), a resting metabolic rate exam, consuming Doubly-Labeled Water, and providing urine and saliva samples. You will also wear an accelerometer for 8-10 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your energy expenditure will be measured at pre-dose, 4 and 5 hours post-dose, and 8-10 days post-dose of the Doubly-Labeled Water.
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Validating a New Machine-Learned Accelerometer Algorithm Using Doubly Labeled Water
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Scott Strath, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Milwaukee
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Accuracy of accelerometer derived estimations of total daily energy expenditure (TDEE, kcals/day).8-10 days monitoring
Accelerometer estimations will be derived by different algorithms available in the literature, as well as from a newly developed algorithm that distinguishes between those with and without movement limitations. Accelerometer estimations of TDEE will be compared to those values obtained by the criterion doubly-labeled water technique.
- Precision of accelerometer derived estimations of total daily energy expenditure (TDEE, kcals/day).8-10 days monitoring
Accelerometer estimations will be derived by different algorithms available in the literature, as well as from a newly developed algorithm that distinguishes between those with and without movement limitations. Accelerometer estimations of TDEE will be compared to those values obtained by the criterion doubly-labeled water technique.
- Total Daily Energy Expenditure (TDEE) (via DLW)pre-dose; 4 hours and 5 hours post-dose, and 8-10 days post-dose
Total daily energy expenditure (TDEE) over the 8-10 day period as measured by the difference in presence of isotopes in the samples at Visit 3. The 18-O and deuterium exit the body through slightly different mechanisms, so when we examine the difference in levels present at the end of the 8-10 day period between Visit 2 and Visit 3, we can estimate carbon dioxide (CO2) production and hence, energy expenditure. The samples taken at Visit 2 provide the baseline information required to analyze the samples taken at Visit 3 and calculate TDEE.