Optimizing PrEP Uptake and Adherence Among Male Sex Workers

This study, called "PrEPare for Work," is testing a new approach to help male sex workers start and stick with PrEP (pre-exposure prophylaxis), a medication that prevents HIV. The study will involve about 500 participants and is currently unclear if it's recruiting. It has two main parts: first, a trained case manager will help you get connected to doctors who can prescribe PrEP. Second, once you have PrEP, you'll receive one-on-one counseling and daily text messages to help you take it regularly. The study will measure how many people start PrEP after two months and how well they take it after 12 months. To join, you must be a man aged 18 or older, have had condomless anal sex with another man in the past three months, and have exchanged sex for money or other items with another man in the past three months. You also can't be currently taking PrEP and must be HIV-negative or unsure of your status.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It is a randomized controlled trial (RCT) and plans to enroll 500 participants.
What's involved
Participants will receive a trained case manager to help with PrEP linkage and three weekly adherence intervention sessions. Personalized daily text message reminders will also be provided.
Compensation
Not stated in the trial record.
Follow-up
PrEP initiation will be measured at 2 months post Stage 1 randomization, and PrEP adherence will be measured at 12 months post Stage 2 randomization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05736614

Optimizing PrEP Uptake and Adherence Among Male Sex Workers

Recruiting
NAAges 18+InterventionalPrevention
Brown University
~500 participants
Updated 2025-05-09 on ClinicalTrials.gov
What's tested:Stage 1 Strength Based Case Management (SBCM) ConditionStage 2 PrEPare for Work Intervention Condition

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Stage one: PrEP initiation
Measured over 2-month post Stage 1 randomization
+1 more outcome measured
Prevention
5 sites across 2 states
Rhode Island4
California1
  • Katie Biello, PhD · PRINCIPAL_INVESTIGATOR · Brown University School of Public Health

Opens a ready-to-send draft in your own email app — review before sending.

  • Stage one: PrEP initiation2-month post Stage 1 randomization

    Stage one: PrEP initiation will be measured via verification of prescription filled within two months post-randomization, associated medical records from a PrEP prescriber, and self-report.

  • Stage two: PrEP adherence12-month post Stage 2 randomization

    Stage two: PrEP adherence will be measured via tenofovir concentration in hair. Self-reported adherence will supplement biological monitoring data at 4-month intervals.