Trigeminal Evoked Responses to Improve Rhizotomy for Trigeminal Neuralgia

This study is looking at a new way to improve a surgery called rhizotomy for people with trigeminal neuralgia (TGN). TGN causes severe, shock-like facial pain. Researchers want to see if measuring "Trigeminal Somatosensory Evoked Potentials" (TSEPs) during rhizotomy surgery is possible and helpful. TSEPs involve placing a small electrode on your skin to stimulate a nerve and measuring brain activity. If you are an adult scheduled for rhizotomy surgery for facial pain, you might be able to join. The study will consider itself successful if it's shown that routinely using TSEPs during rhizotomy is practical. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 30 participants. It is a prospective cohort study, meaning participants are followed forward in time.
What's involved
If you have TGN, TSEPs will be measured before and during your rhizotomy surgery. Healthy volunteers will have non-invasive TSEP recordings in a lab setting.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study, feasibility, will be measured at 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05738096

Trigeminal Evoked Responses to Improve Rhizotomy

Recruiting
EARLY_PHASE1Ages 18+InterventionalSupportive care
University of Minnesota
~30 participants
Updated 2025-11-26 on ClinicalTrials.gov
What's tested:TSEP + rhizotomy surgeryTSEPs recording only

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility
Measured over 3 years
Trigeminal Neuralgia
Rhizotomy

NCT05738096

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Minnesota

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • David P Darrow, MD · PRINCIPAL_INVESTIGATOR · University of Minnesota

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Eligibility criteria

Inclusion

Adults of 18 years or older
Scheduled to undergo percutaneous rhizotomy for facial pain

Exclusion

For TGN: Facial pain of unclear origin (i.e. not clearly TGN pain) or Rhizotomy procedure canceled
For Healthy control: Diagnosis or history of facial pain such as TMD or TGN, History of migraine, History of any functional pain disorder: fibromyalgia, IBS, CRPS or Recent chronic pain (within last month)
  • Feasibility3 years

    total study procedure completion rate