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Speech-Language Intervention for Bilingual Speakers with Primary Progressive Aphasia

This study is for bilingual individuals with Primary Progressive Aphasia (PPA), a condition causing difficulties with speech and language. It aims to see how well two different speech-language therapies work: Video-Implemented Script Training for Aphasia (VISTA) and Lexical Retrieval Training (LRT). VISTA helps participants practice speaking personal sentences, while LRT focuses on naming familiar items. Researchers want to understand how these tailored interventions affect bilingual individuals with PPA. You may be eligible if you are between 40 and older, have PPA, and are bilingual in Spanish and Catalan or Spanish and English. The study will measure success by looking at how many correct words you can speak from trained scripts or how accurately you can name items. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 60 participants. It is a Stage 2 efficacy clinical trial, meaning it aims to establish the effects of the interventions.
What's involved
Participants will receive either Video-Implemented Script Training for Aphasia (VISTA) or Lexical Retrieval Training (LRT). Your progress will be measured at the start, after 4.5 weeks, after 9 weeks, and then 6 months and 1 year after treatment ends.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months and 1 year after treatment to assess long-term effects.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05741853

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

Recruiting
NAAges 40+InterventionalTreatment
Stephanie Grasso
~60 participants
Updated 2026-06-10 on ClinicalTrials.gov
What's tested:Video-Implemented Script Training for Aphasia (VISTA)Lexical Retrieval Training (LRT)

At a glance

Recruiting sites
2 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent correct intelligible words from trained/untrained scripts
Measured over Pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
+1 more outcome measured

Conditions

Primary Progressive Aphasia
Dementia
Dementia, Frontotemporal
Alzheimer Disease
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Apraxia, Motor
Dysarthria
Communication Disorders
Language Disorders
Speech Disorders
Neurocognitive Disorders
Aphasia
Bilingual Aphasia

Explore related trials

Primary Progressive Aphasia

Where it's being run

3 sites across 3 states
Texas1
Barcelona1
Spain1

Study leadership

  • Stephanie M Grasso, Ph.D · PRINCIPAL_INVESTIGATOR · University of Texas at Austin
  • Miguel Ángel Santos Santos, MD, PhD · PRINCIPAL_INVESTIGATOR · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Who to contact

Camille Wagner Rodríguez, M.S., CCC-SLP
[email protected]
512-471-4119
Email the study team

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Eligibility criteria

Inclusion

Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
Bilingual in Spanish and Catalan or bilingual in Spanish and English
Different proficiency levels across languages are expected, any prior experience in both languages is acceptable
Intervention study: Score of 15 or higher on the Mini-Mental State Examination

Exclusion

Other central nervous system or medical diagnosis that can cause symptoms
Other psychiatric diagnosis that can cause symptoms
Significant, uncorrected visual or hearing impairment that would interfere with participation
Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)
Intervention Study: Score of less than 15 on the Mini-Mental State Examination

What this trial measures

  • Percent correct intelligible words from trained/untrained scriptsPre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment

    Percent of intelligible, scripted words for trained scripts and untrained scripts

  • Percent correct spoken naming of trained/untrained nounsPre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment

    Percent of correctly named trained pictured items and untrained pictured items