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NCT05742360

Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

Active, Not Recruiting
Not specifiedAges 18–75Observational
Ohio State University
~227 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:CPAP therapy

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in 24-hour Mean Blood Pressure
Measured over Change from baseline 24-hour Mean Blood Pressure at 6-months after initiation of CPAP therapy

Conditions

Obstructive Sleep Apnea

Explore related trials

Obstructive Sleep Apnea

Where it's being run

2 sites across 2 states
Ohio1
Pennsylvania1

Study leadership

  • Ulysses Magalang, MD · PRINCIPAL_INVESTIGATOR · Ohio State University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18-75 years
Moderate-severe OSA (defined as ODI ≥10 events/hour) via Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) done based on clinical grounds
Excessively sleepy subtype determined by patient-reported symptoms
Willing to accept CPAP therapy
An elevated baseline office BP defined as ≥120 or ≥80 mmHg
Planned PAP (CPAP or bi-level PAP) treatment by treating provider

Exclusion

Recent changes (within 3 months) to BP medications among those who are on these medications
Unable to apply ABPM cuff
Current use of CPAP or other OSA treatments
Resting, awake SaO2 \<90% or use of home oxygen therapy
New York Heart Association (NYHA) categories III-IV of heart failure
Presence of Cheyne-Stokes Respiration (CSR) in sleep study identified by typical crescendo-decrescendo pattern of respiration with associated apneas and/or hypopneas in the absence of inspiratory flow limitation
Predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events \[apnea or hypopnea\])
Life expectancy \<2 years
Pregnancy
Clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
Systolic BP \> 180 mmHg

What this trial measures

  • Change in 24-hour Mean Blood PressureChange from baseline 24-hour Mean Blood Pressure at 6-months after initiation of CPAP therapy

    24-hour Mean Blood Pressure obtained from ambulatory blood pressure monitoring (ABPM)