Study on Weight Regain After Behavioral Weight Loss

This study aims to understand why some people regain weight after successfully losing it through a behavioral weight loss program. You would participate in a behavioral lifestyle program, up to 20 weeks long, designed to help you lose at least 7% of your starting weight. Researchers will then observe your weight changes for 52 weeks to identify factors that contribute to weight regain. To join, you should be between 25 and 59 years old, have a BMI (Body Mass Index) between 30 and 40, and have a smartphone or computer with internet access. The study is looking to enroll 205 participants, but its current recruitment status is unclear.

Study design
This is an interventional study with an enrollment goal of 205 participants. It is not specified if it is randomized or blinded.
What's involved
You would participate in a behavioral weight loss program for up to 20 weeks, aiming for at least 7% weight loss. After reaching this goal, you would stabilize your weight for 2 weeks, followed by a clinical examination and further assessments over 52 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 52 weeks after stabilizing their weight following initial weight loss.

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NCT05748158

A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

Recruiting
NAAges 25–59InterventionalBasic science
University of Pittsburgh
~205 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Weight loss

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Weight change from end of weight stabilization following at least 7 percent weight loss to 52 weeks after weight stabilization following at least 7 percent weight loss
Measured over End of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss
+1 more outcome measured
Obesity
3 sites across 2 states
Pennsylvania2
New York1
  • Steven Belle, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
  • Dympna Gallagher, EdD · PRINCIPAL_INVESTIGATOR · Columbia University
  • Susan Roberts, PhD · PRINCIPAL_INVESTIGATOR · Dartmouth College

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  • Weight change from end of weight stabilization following at least 7 percent weight loss to 52 weeks after weight stabilization following at least 7 percent weight lossEnd of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss

    Percentage of lost weight that is regained

  • Weight change from end of weight stabilization following at least 7 percent weight loss to 52 weeks after weight stabilization following at least 7 percent weight lossEnd of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss

    Weight regained