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Anxiety Sensitivity Treatment for Anxiety in Alzheimer's

This study is testing a computerized treatment called Computerized Anxiety Sensitivity Treatment (CAST) to see if it can reduce anxiety in older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease. It's also comparing CAST to a Health Education Control (HEC), which is a computerized presentation on healthy behaviors. The study wants to see if CAST helps reduce anxiety and related symptoms for patients, and if it lessens the burden on their care partners. Researchers will measure changes in anxiety sensitivity (how much you fear anxiety symptoms) right after treatment and changes in anxiety one month later. The study is looking for 388 participants, and its current status is unclear. You can join if you are 60 or older and have a care partner (someone who provides emotional or physical support) who is 18 or older and will also participate.

Study design
This is an interventional study involving 388 participants, divided into pairs (dyads) of a patient and their care partner. Dyads will be randomly assigned to receive either the CAST or HEC intervention.
What's involved
You and your care partner will have six in-person visits, including a baseline assessment, two intervention sessions, and three follow-up assessments. You will also complete daily surveys on a phone or tablet for three weeks around the intervention sessions.
Compensation
Not stated in the trial record.
Follow-up
Participants will have follow-up assessments at 1, 3, and 6 months after the intervention.

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NCT05748613

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

Recruiting
NAAges 60+InterventionalTreatment
Florida State University
~388 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Computerized Anxiety Sensitivity TreatmentHealth Education Control

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in anxiety sensitivity pre intervention to posttreatment.
Measured over Baseline to immediately after the intervention
+1 more outcome measured

Conditions

Anxiety
Mild Cognitive Impairment
Alzheimer Disease
Dementia

Explore related trials

Alzheimer's DiseaseAnxietyDementiaMild cognitive disorder

Where it's being run

3 sites across 2 states
Ohio2
Florida1

Who to contact

Norman B Schmidt, Ph.D.
[email protected]
8506451766
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient age 60+
Care partner 18+
Has care partner who will participate ("someone you have a reciprocal relationship with who provides you with emotional or physical support and helps with decision-making. This could be a spouse or significant other, relative, or close friend whom you spend a significant amount of time with.")
Has smartphone or access to Wi-Fi
Score of 20 or above on the PROMIS-Anxiety short form (patient only) OR
Score of 5 or above on SSASI (patient only) OR
Score of 31 or above on NIH Toolbox Perceived Stress Scale score (patient only)

Exclusion

Issues with seeing or hearing that would prevent reading or listening to computer presentations
Medical conditions that would preclude participation in study
Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)
Issues with seeing or hearing that would prevent reading or listening to computer presentations
Medical conditions that would preclude participation in study
Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)

What this trial measures

  • Change in anxiety sensitivity pre intervention to posttreatment.Baseline to immediately after the intervention

    Anxiety sensitivity will be measured using the Anxiety Sensitivity Index-3 (ASI-3). The ASI-3 is an 18-item self report measure with possible scores ranging from 0 to 72. Higher scores indicate higher anxiety sensitivity.

  • Change in anxiety pre intervention to 1-month follow-up.Baseline to 1-month follow-up

    Anxiety will be assessed using the Patient-Reported Outcomes Measurement Information System - Anxiety (PROMIS Anxiety) Short Form 8a self-report measure. The PROMIS Anxiety is an 8-item self report questionnaire with possible scores ranging from 8 to 40. Higher scores indicate more anxiety.