IRX-101 for Eye Pain After Injections

This study is testing a new eye drop called IRX-101. It's designed to see how safe and well-tolerated IRX-101 is compared to povidone-iodine, which is a common antiseptic, in people who get injections in their eye for retinal disease. The main goal is to see if IRX-101 can reduce eye pain one hour after these injections. You can join if you are 18 or older and are already receiving anti-VEGF injections in your eye. The study is looking for 240 participants, but its current status is unclear.

Study design
This is a randomized, double-masked study comparing IRX-101 to povidone-iodine. It plans to enroll 240 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint assesses pain one hour after injection, but overall follow-up duration is not specified.

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NCT05750589

Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections

Not Yet Recruiting
PHASE3Ages 18+InterventionalTreatment
iRenix Medical, Inc.
~240 participants
Updated 2026-04-03 on ClinicalTrials.gov
What's tested:IRX-101Providone-Iodine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assessment of post-intravitreal injection eye pain
Measured over Demonstrate a reduction in mean 1-hr post-injection pain scores
Retinal Disease
1 sites across 1 states
Texas1
  • Stephen Smith, MD · STUDY_CHAIR · Founder

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  • Assessment of post-intravitreal injection eye painDemonstrate a reduction in mean 1-hr post-injection pain scores

    Demonstrate the superiority of IRX-101 compared to PI in terms of reducing patient-reported post-intravitreal injection eye pain; pain will be assessed using the visual analog pain scale, a validated patient-reported outcome measure (questionnaire) for assessing patient's subjective pain and discomfort