This study aims to understand why some people with heart failure don't respond well to 'water pills' (diuretics). Researchers are testing different combinations of medicines: bendroflumethiazide, amiloride, and a placebo (an inactive substance), all added to bumetanide. You might be able to join if you have a heart failure diagnosis, are at least 18 years old, and your heart failure medications are stable. The study will look at how these drug combinations affect your body's ability to get rid of excess salt and water. The goal is to find better ways to treat heart failure. The current status of this study is unclear.

Study design

This is a randomized, placebo-controlled, double-blind, double-dummy, crossover study planning to enroll 50 participants.

What's involved

You will receive different drug combinations on Days 0, 7, 14, and 21. Your kidney function (FENa) and sodium reabsorption will be measured at 21 days.

Compensation

Not stated in the trial record.

Follow-up

The primary measurements for the study are taken at 21 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.