This study is comparing two ways to manage Barrett's esophagus with low-grade dysplasia (abnormal cells in the esophagus that could become cancer). You would either receive endoscopic surveillance, which involves regular checks with a scope and biopsies (small tissue samples), or endoscopic eradication therapy. Endoscopic eradication therapy is a procedure that uses a scope to remove or burn away the abnormal cells. The goal is to see which approach is better at preventing the abnormal cells from getting worse. This study is looking for 680 participants between 18 and 89 years old who have Barrett's esophagus with low-grade dysplasia. The study's current status is unclear.

Study design

This is an interventional study that will randomly assign participants to either endoscopic eradication therapy or endoscopic surveillance. It plans to enroll 680 participants.

What's involved

If you have newly diagnosed low-grade dysplasia, you would have surveillance endoscopies every 6 months for the first year, then annually. If you have had low-grade dysplasia for over a year, you would have annual endoscopies. If you receive endoscopic eradication therapy, you would have treatments every 2-3 months until the abnormal cells are gone or you've had 5 treatments.

Compensation

Not stated in the trial record.

Follow-up

The maximum follow-up period for participants is 4 years, with neoplastic progression (the abnormal cells getting worse) measured from baseline through study completion.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.