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Feasibility of Transcranial Focused Ultrasound for Brain Tumor Imaging

This study is looking into whether transcranial focused ultrasound (tFUS) can be used to image brain tumors. tFUS is a non-invasive (does not involve cutting the body) way to get high-resolution images of the brain. You might be able to join if you are at least 18 years old, scheduled for brain surgery, and will be under general anesthesia. The main goal is to see if tFUS imaging is possible (feasible) at the start of the study. This study plans to enroll 15 participants and is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 15 participants. It is designed to test the feasibility of a new imaging method.
What's involved
If you participate, you will have a standard MRI scan and an additional tFUS imaging session, which will take up to 15 minutes. This will happen before your scheduled brain surgery.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study is measured at baseline (the start of the study), so no long-term follow-up is specified.

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NCT05755399

Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor

Recruiting
NAAges 18+Interventional
University of Minnesota
~15 participants
Updated 2026-05-19 on ClinicalTrials.gov
What's tested:Brain imaging using transcranial focused ultrasound (tFUS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Test feasibility
Measured over baseline

Conditions

Cranial Neurosurgery

Explore related trials

Brain Neoplasm

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • David Darrow, MD · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

David Darrow, MD
[email protected]
612-624-6666
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to undergo informed consent
Scheduled and present for brain surgery
General Anesthesia planned
Neuronavigation used for surgery
Thin cut post-contrast imaging available for coregistration
At least 18 years of age

Exclusion

Awake craniotomy planned
Unhealed wounds or infection of scalp
Diseases and conditions that would increase the morbidity and mortality of craniotomy and tumor resection (e.g. cardiopulmonary issues) in the opinion of the PI.
Pregnancy (also generally required for surgery)

What this trial measures

  • Test feasibilitybaseline

    For each participant feasibility is defined as 1 when any ultrasound slices are obtained and segmented. If tumor segmentation cannot be performed then this will be reported as 0, meaning not feasible. The result at the group level is a feasibility measure, i.e., the proportion of participants for whom the protocol was feasible.