Oxygen Toxicity: Mechanisms in Humans
This study aims to understand how oxygen toxicity, a risk for scuba divers, happens. Researchers want to see how factors like sleep deprivation, medications (caffeine, methylphenidate), and carbon dioxide exposure (simulated with sodium bicarbonate) affect this condition. They also want to know how respiratory muscle training and being immersed in water play a role. You might be eligible if you are a non-smoker between 18 and 45 years old, with specific fitness levels. The study will measure your hypercapnic ventilatory response (how your breathing changes with high carbon dioxide) after three months to see the effects of these interventions. The current status of this study is unclear, and it plans to enroll 62 participants.
- Study design
- This interventional study plans to enroll 62 participants. It is not specified if it is randomized, blinded, or what phase it is in.
- What's involved
- You would undergo a screening exam, train your respiratory muscles, and exercise on a cycle ergometer both dry and underwater/under pressure.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your hypercapnic ventilatory response will be measured at 3 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Oxygen Toxicity: Mechanisms in Humans
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Derek B Covington, MD · PRINCIPAL_INVESTIGATOR · Duke University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Hypercapnic ventilatory response3 months