Oxygen Toxicity: Mechanisms in Humans

This study aims to understand how oxygen toxicity, a risk for scuba divers, happens. Researchers want to see how factors like sleep deprivation, medications (caffeine, methylphenidate), and carbon dioxide exposure (simulated with sodium bicarbonate) affect this condition. They also want to know how respiratory muscle training and being immersed in water play a role. You might be eligible if you are a non-smoker between 18 and 45 years old, with specific fitness levels. The study will measure your hypercapnic ventilatory response (how your breathing changes with high carbon dioxide) after three months to see the effects of these interventions. The current status of this study is unclear, and it plans to enroll 62 participants.

Study design
This interventional study plans to enroll 62 participants. It is not specified if it is randomized, blinded, or what phase it is in.
What's involved
You would undergo a screening exam, train your respiratory muscles, and exercise on a cycle ergometer both dry and underwater/under pressure.
Compensation
Not stated in the trial record.
Follow-up
Your hypercapnic ventilatory response will be measured at 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05761756

Oxygen Toxicity: Mechanisms in Humans

Recruiting
NAAges 18–45InterventionalPrevention
Duke University
~62 participants
Updated 2025-10-23 on ClinicalTrials.gov
What's tested:Sleep DeprivationCaffeineMethylphenidateCarbon Dioxide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hypercapnic ventilatory response
Measured over 3 months
Oxygen Toxicity
Hypercapnia
Seizures
1 sites across 1 states
North Carolina1
  • Derek B Covington, MD · PRINCIPAL_INVESTIGATOR · Duke University

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Equal numbers of male and female
Non-smokers
Aged 18-45 years
Males will be required to have VO2 peak \> or equal to mL/kg min
and females \> or equal to 30 mL/kg min

Exclusion

Pregnancy
Cardiorespiratory disease, including hypertension
Neuromuscular disease
Anemia
History of hemoglobinopathy, including sick cell disease and trait
  • Hypercapnic ventilatory response3 months