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Understanding Exercise Responses in Childhood Cancer Survivors

This study at St. Jude Children's Research Hospital is looking at how young adult survivors of childhood acute lymphoblastic leukemia (ALL) feel about exercise. Researchers want to see if a special cognitive task, called the Personalized Single-Category Implicit Association Test (PSC-IAT), can accurately measure their feelings towards exercise. You would perform this cognitive task before and after a cardiovascular stress test, and then participate in an interview about your experiences. This study is for ALL survivors aged 18-39 who did not receive radiation to the brain and are not currently meeting physical activity guidelines. The main goal is to see if the PSC-IAT is a good tool to use in this group of survivors.

Study design
This is an observational study with a planned enrollment of 125 participants. It is not testing a new treatment, but rather observing and collecting information.
What's involved
You would perform a cognitive task three times before and after a scheduled cardiovascular stress test. You would also participate in a qualitative interview about the cognitive task and your feelings during exercise.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured before and after cardiovascular stress testing at baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05763290

Childhood Cancer Survivors' Affective Response to Exercise

Active, Not Recruiting
Not specifiedAges 18–39Observational
St. Jude Children's Research Hospital
~125 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:Affective Response to Exercise

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Implicit Association Bias Testing
Measured over Before and after Cardiovascular Stress Testing at Baseline
+1 more outcome measured

Conditions

ALL, Childhood
Acute Lymphoblastic Leukemia

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NCT05763290

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • St. Jude Children's Research Hospital

    Memphis, Tennesseeno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Kirsten Ness, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Deo Srivastava, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Lisa Jacola, PhD, ABPP-CN2 · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Rachel Webster, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Tara Brinkman, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Kevin Krull, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Melissa Hudson, MD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital
  • Leslie Robinson, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Participants enrolled in St. Jude Lifetime Cohort (SJLIFE) aged 18-39 years at completion of on campus visit
Primary diagnosis of acute lymphoblastic leukemia (ALL)
No cranial radiation therapy (CRT) as part of treatment for ALL
Identify as physically inactive (do not meet Centers for Disease Control and Prevention (CDC) guidelines of 150 minutes of moderate physical activity per week or 75 minutes of vigorous physical activity per week)
Women who are not currently pregnant

Exclusion

Individuals who cannot speak, read, and/or understand English.
Individuals with an estimated IQ of \<70 and/or per PI discretion
Individuals with any contraindication to stress testing (i.e. cardiovascular complications)
Women who are currently pregnant

What this trial measures

  • Implicit Association Bias TestingBefore and after Cardiovascular Stress Testing at Baseline

    Participants' implicit associations with exercise will be measured using the Personalized Single-Category Implicit Association test (PSC-IAT).

  • Behavioral Regulation of Exercise Questionnaire (BREQ-2):Before and after Cardiovascular Stress Testing at Baseline

    The Behavioral Regulation of Exercise Questionnaire (BREQ-2) will be administered once to participants in this study to assess trait-level affective motivation.