Hyperpolarized 129Xe MRI for Lung Health

This study is looking at young adults who are already part of the American Lung Association Lung Health Cohort. Researchers will use a special type of MRI called Hyperpolarized 129Xe MRI to look at your lungs. This involves inhaling a gas called hyperpolarized 129Xe, which helps the MRI machine see your lungs better. The goal is to understand lung structure and function, and to identify early signs of lung problems that could lead to chronic lung disease. You can join if you are 25 to 35 years old, have had a CT scan for the Lung Health Cohort study within the last two years, and don't have certain implanted medical devices like pacemakers. The main thing they will measure is something called the Xe-MRI Apparent Diffusion Coefficient at your first imaging visit. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe participants without providing a specific treatment. It plans to enroll 260 healthy individuals.
What's involved
You would undergo Hyperpolarized 129Xe MRI imaging. You must have completed a CT scan for the Lung Health Cohort study within two years of the MRI date.
Compensation
Not stated in the trial record.
Follow-up
The primary measurement is taken at the baseline imaging timepoint. Further follow-up is not specified.

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NCT05766384

Hyperpolarized 129Xe MRI Lung Health Cohort

Recruiting
Not specifiedAges 25–35Observational
University of Kansas Medical Center
~260 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Hyperpolarized Xe129

At a glance

Recruiting sites
3 of 6 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Xe-MRI Apparent Diffusion Coefficient
Measured over At baseline imaging timepoint
Healthy
6 sites across 5 states
Texas2
Illinois1
Iowa1
Kansas1
North Carolina1

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Eligibility criteria

Inclusion

Is enrolled in the American Lung Association Lung Health Cohort Study.
Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.

Exclusion

Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution).
Is pregnant or breastfeeding
Oxygen saturation (SpO2) \<88% on room air or with supplemental oxygen.
  • Xe-MRI Apparent Diffusion CoefficientAt baseline imaging timepoint

    Correlation of Xe-MRI with FEV1/FVC and other measures of lung function