FEED-Cystic Fibrosis (FEED-CF) Diet Study
This study, called FEED-CF, is looking at how diet affects people with cystic fibrosis (CF). Many adults with CF develop diabetes, and the typical high-calorie, high-fat CF diet might play a role in this. Researchers want to see if a low-added sugar, high-fat diet can improve diabetes risk and reduce fat around organs (visceral fat) compared to a standard CF diet. You might be able to join if you have a confirmed CF diagnosis, are 18 or older, and consume more than 16 teaspoons of added sugar daily. The study will measure changes in your body's insulin response and visceral fat over 8 weeks. The current status of this study is unclear.
- Study design
- This study plans to enroll 60 participants. You would be randomly assigned to either a low-added sugar, high-fat diet or a high-added sugar, high-fat CF diet.
- What's involved
- You would follow a specific diet for 8 weeks, with all foods provided. There will be a total of 4 study visits at the Emory Hospital clinical research unit.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your insulin response and visceral fat will be measured at baseline and 8 weeks after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
FEED-Cystic Fibrosis (FEED-CF)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jessica A Alvarez, PhD, RD · PRINCIPAL_INVESTIGATOR · Emory University
Who to contact
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What this trial measures
- Change in acute insulin response to arginine (AIRarg) from baselineBaseline and 8 weeks post intervention
Participants will undergo a Glucose-Potentiated Arginine Stimulation (GPA) Test after a 10-12 hour overnight fast to measure acute insulin (AIRarg) responses during a 230 and 340 mg/dl glucose clamp. This test will measure changes in beta cell secretory capacity.
- Change in acute C-peptide (ACRarg) from baselineBaseline and 8 weeks post intervention
Participants will undergo a Glucose-Potentiated Arginine Stimulation (GPA) Test after a 10-12 hour overnight fast to measure acute C-peptide (ACRarg) responses during a 230 and 340 mg/dl glucose clamp. This test will measure changes in beta cell secretory capacity.
- Change in visceral adipose tissue from baselineBaseline and 8 weeks post intervention
Dual energy X-ray absorptiometry (DEXA)-derived measurement of visceral adipose tissue (VAT) will be assessed with a GE Lunar iDXA machine. This will enable assessment of changes in body composition over the study.
- Change in fasted plasma Eh[CySS] from baselineBaseline and 8 weeks post intervention
Change in plasma Cysteine/Cystine Redox Potential (Eh\[CySS\]) will be measured.