Vaping and Smoking Withdrawal Project
This study is looking at the differences in withdrawal symptoms between people who vape (use e-cigarettes) and people who smoke regular cigarettes. Researchers want to understand how the body reacts when someone stops using nicotine from either vaping or smoking. You might be able to join if you are between 21 and 50 years old and have been vaping or smoking daily for at least six months. To be eligible, a quick test will confirm you have a certain level of nicotine in your system (200+ ng/mL cotinine). The study will compare how anger and anxiety change after a short period without nicotine. This research aims to help develop better ways to treat nicotine addiction.
- Study design
- This interventional study plans to enroll 370 participants, including vapers, smokers, and dual users. Participants will be randomly assigned to the order of their study visits.
- What's involved
- You will complete two 4-hour lab visits. One visit will follow 24 hours of not using any tobacco/nicotine, and the other will follow 24 hours of smoking/vaping as usual.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your withdrawal symptoms will be measured at 0.5 hours and 2.5 hours during the study visits.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Vaping and Smoking Withdrawal Project
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Larry Hawk, PhD · PRINCIPAL_INVESTIGATOR · University at Buffalo
Who to contact
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Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Wisconsin Smoking Withdrawal Scale - anger 0.50.5 hours
anger subscale score
- Wisconsin Smoking Withdrawal Scale - anger 2.52.5 hours
anger subscale score
- Wisconsin Smoking Withdrawal Scale - anx 0.50.5 hours
anxiety subscale score
- Wisconsin Smoking Withdrawal Scale - anx 2.52.5 hours
anxiety subscale score
- Wisconsin Smoking Withdrawal Scale - sad 0.50.5 hours
sadness subscale score
- Wisconsin Smoking Withdrawal Scale - sad 2.52.5 hours
sadness subscale score
- Wisconsin Smoking Withdrawal Scale - conc 0.50.5 hours
difficulty concentrating subscale score
- Wisconsin Smoking Withdrawal Scale - conc 2.52.5 hours
difficulty concentrating subscale score
- Wisconsin Smoking Withdrawal Scale - sleep 0.50.5 hours
sleep subscale score
- Wisconsin Smoking Withdrawal Scale - sleep 2.52.5 hours
sleep subscale score
- Wisconsin Smoking Withdrawal Scale - appetite 0.50.5 hours
appetite subscale score
- Wisconsin Smoking Withdrawal Scale - appetite 2.52.5 hours
appetite subscale score
- Mood and Physical Symptoms Scale - 0.50.5 hours
single-item indicators of withdrawal facets
- Mood and Physical Symptoms Scale - 2.52.5 hours
single-item indicators of withdrawal facets
- Minnesota Nicotine Withdrawal Scale - 0.50.5 hours
17-item version with indicators of various withdrawal facets
- Minnesota Nicotine Withdrawal Scale - 2.52.5 hours
17-item version with indicators of various withdrawal facets
- Positive and Negative Affect Scale - PA 0.50.5 hours
positive affect subscale score
- Positive and Negative Affect Scale - PA 2.52.5 hours
positive affect subscale score
- Positive and Negative Affect Scale - NA 0.50.5 hours
negative affect subscale score
- Positive and Negative Affect Scale - NA 2.52.5 hours
negative affect subscale score
- Snaith-Hamilton Pleasure Scale 0.50.5 hours
total score
- Snaith-Hamilton Pleasure Scale 2.52.5 hours
total score
- Questionnaire on Vaping Craving 0.50.5 hours
total craving score
- Questionnaire on Vaping Craving 2.52.5 hours
total craving score
- Questionnaire on Smoking Urges - Brief 0.50.5 hours
total craving score
- Questionnaire on Smoking Urges - Brief 2.52.5 hours
total craving score
- PhenX Toolkit Insomnia Severity Index 0.50.5 hours
7-item scale (but item #5 is omitted because of the short time-frame), total score impairment and interference with daily functioning
- PhenX Toolkit Insomnia Severity Index 2.52.5 hours
7-item scale (but item #5 is omitted because of the short time-frame), total score impairment and interference with daily functioning
- Restlessness ratings 0.50.5 hours
3-item scale
- Restlessness ratings 2.52.5 hours
3-item scale
- Restlessness and Agitation Questionnaire - Modified 0.50.5 hours
total score on subset of behavioral indicators
- Restlessness and Agitation Questionnaire - Modified 2.52.5 hours
total score on subset of behavioral indicators
- Identical Pair Continuous Performance Task~2 hours
Sustained attention, or vigilance, is the ability to maintain alertness to detect infrequent target stimuli during a long, monotonous task (e.g., Mackworth, 1948). We will use a version of the identical-pairs continuous performance task (Cornblatt et al., 1988) in which participants attend to a series of 800 4-digit numbers on a computer monitor (100-ms stimulus duration; 1500-ms ISI). Participants are asked to press the keyboard space bar only when the stimulus is identical to the immediately preceding stimulus (10% targets; Cooper et al., 2020; Rhodes \& Hawk, 2016). Percent correct hits (target detections) is the primary outcome.
- n-back working memory task~2 hours
The n-back task (e.g., Strand et al., 2012; Rhodes \& Hawk, 2016) requires indicating whether each stimulus in a rapidly presented series matches the location of the stimulus presented n stimuli before (e.g., n=0,1,2). Stimuli are small grey circles (100 ms; 30% targets). The focus here is on conditions that place marked demands on the "central executive" by requiring ongoing mental manipulation (i.e., n=2; see Baddeley, 2003). Brief practice with a 1-back and 2-back will be followed by 2 100-trial blocks of the 2-back. Accuracy is the primary outcome.
- Stop signal reaction time task~2 hours
We will employ the stop-signal paradigm (Logan et al., 1984), which provides a relatively pure index response inhibition (e.g., Nigg, 2001). In our typical task (e.g., Hawk et al., 2018; Rhodes \& Hawk, 2016), participants button press to indicate whether the "go" signal (\<-- or --\>) is pointing left or right. After a brief "go" practice, the stop signal (100-ms tone) is introduced, and participants complete 3 64-trail bocks during with they are asked to respond as quickly as possible but to not respond on stop signal trials (25% of trials). The stop signal occurs after go signal onset and adjusts dynamically across trials to yield \~50% inhibition (Logan et al., 1997). The primary outcome is stop signal reaction time (SSRT), an estimate of the speed of inhibition.
- kcal consumed3 hours
Fat, protein, and carbohydrate calories, and total calories, consumed during the visit.
- Hypothetical commodity purchase task - vaping intensity 0.50.5 hours
Intensity of demand
- Hypothetical commodity purchase task - vaping intensity 2.52.5 hours
intensity of demand
- Hypothetical commodity purchase task - vaping persistence 0.50.5 hours
persistence of demand
- Hypothetical commodity purchase task - vaping persistence 2.52.5 hours
persistence of demand
- Hypothetical commodity purchase task - smoking intensity 0.50.5 hours
intensity of demand
- Hypothetical commodity purchase task - smoking intensity 0.52.5 hours
intensity of demand
- Hypothetical commodity purchase task - smoking persistence 0.50.5 hours
persistence of demand
- Hypothetical commodity purchase task - smoking persistence 2.52.5 hours
persistence of demand
- Choice Behavior Under Cued Conditions (CBUCC) Task - spend vape3 hours
Spending for vape puffs
- Choice Behavior Under Cued Conditions (CBUCC) Task - spend cig3 hours
Spending for cigarette puffs
- Choice Behavior Under Cued Conditions (CBUCC) Task - spend water3 hours
Spending for water control
- Choice Behavior Under Cued Conditions (CBUCC) Task - crave vape3 hours
Craving for vape puffs
- Choice Behavior Under Cued Conditions (CBUCC) Task - crave cig3 hours
Craving for cigarette puffs