Parenting Skills Group for Mothers With Postpartum Depression

This study is looking at how an 8-week parenting program called Circle of Security Parenting (COSP) can help mothers with postpartum depression. COSP teaches parents to understand and respond to their baby's needs. Researchers want to see if COSP improves depression symptoms, strengthens the bond between mother and baby, and changes certain genetic markers (like OXTR receptor gene methylation) in both mothers and infants. They also want to know if COSP affects the baby's social behavior long-term. You can join if you are a mother aged 18-50 with an infant 3-14 months old, whether or not you are experiencing symptoms of depression. The study is currently recruiting participants.

Study design
This is an interventional study planning to enroll 750 participants. It is not specified if it is randomized or blinded.
What's involved
You will participate in an 8-week COSP program delivered remotely via Zoom. Researchers will collect biological samples, questionnaires, developmental assessments, and direct observations at several time points.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 4.5 years after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05772897

Parenting Skills Group for Mothers With Postpartum Depression

Recruiting
NAAges 18–50InterventionalTreatment
University of Colorado, Denver
~750 participants
Updated 2023-11-30 on ClinicalTrials.gov
What's tested:Circle of Security Parenting program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in methylation of OXTR receptor gene rs53576
Measured over Time1 (baseline), Time4 (1 week post-intervention), Time5 (6 months post-intervention), Time6 (12 months post-intervention) Time7 (average 4.5 years post-intervention)
+3 more outcomes measured
Postpartum Depression
1 sites across 1 states
Colorado1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Mothers aged 18-50 years old with infants aged 3-14 months old
Mothers who are experiencing symptoms of depression and mothers who are not experiencing symptoms of depression (non-depressed controls) are encouraged to participate.

Exclusion

Mothers with severe psychopathology (such as bipolar disorder, schizophrenia, personality disorders, among others)
Infants with major medical problems that may interfere with a mother's ability to participate in and benefit from the intervention
  • Change in methylation of OXTR receptor gene rs53576Time1 (baseline), Time4 (1 week post-intervention), Time5 (6 months post-intervention), Time6 (12 months post-intervention) Time7 (average 4.5 years post-intervention)

    Buccal swabs from mother and infant

  • Changes in Beck Depression Inventory, Second Edition (BDI-II) ScoreTime1 (baseline), Time2 (1 week pre-intervention), Time3 (week 5 of intervention), Time4 (1 week post-intervention), Time5 (6 months post-intervention), Time6 (12 months post-intervention), Time7 (average 4.5 years post-intervention)

    The BDI-II is a brief, self-report inventory designed to measure the severity of depression symptomatology for ages 13-80 years old and takes approximately 5 minutes to complete. The BDI-II is comprised of 21 items. Each item is scored on a scale of 0 to 3, with a total score range of 0-63. Total score of \<14 indicates minimal range, 14-19 indicates mild severity, 20-28 indicates moderate severity, and 29-63 indicates a score in the severe range. Higher scores indicate greater levels of depression.

  • Changes Postpartum Depression Screening Scale (PDSS) ScoreTime1 (baseline), Time2 (1 week pre-intervention), Time3 (week 5 of intervention), Time4 (1 week post-intervention), Time5 (6 months post-intervention), Time6 (12 months post-intervention)

    The PDSS is a 35-item self-report measure helps clinicians identify mothers suffering from postpartum depression. It takes about 5-10 minutes to complete and is written at a third-grade reading level. Mothers respond using a 5-point scale ranging from "strongly disagree" to "strongly agree" and yields an overall severity score. A higher score indicates more severe depression.

  • Changes in Dyadic Adjustment Scale (DAS) ScoreTime1 (baseline), Time2 (1 week pre-intervention), Time3 (week 5 of intervention), Time4 (1 week post-intervention), Time5 (6 months post-intervention), Time6 (12 months post-intervention), Time7 (average 4.5 years post-intervention)

    A 32-item measure of relationship quality. The scale is divided into 4 subscales: (1) Dyadic Consensus - degree to which respondent agrees with partner (2) Dyadic Satisfaction -- degree to which respondent feels satisfied with partner (3) Dyadic Cohesion -degree to which respondent and partner participate in activities together (4) Affectional Expression -degree to which respondent agrees with partner regarding emotional affection. Scores range from 0-151, with higher scores being indicative of more positive dyadic adjustment and lower distress level.