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Aerobic Exercise During Chemotherapy for Colon Cancer

This study is looking at whether aerobic exercise can help people with stage II or III colon cancer who are starting chemotherapy. You might be able to join if you're 18 or older, have had surgery for your colon cancer, and don't currently exercise much. The study will compare moderate- to vigorous-intensity aerobic exercise to progressive stretching. Researchers want to see if aerobic exercise can improve how well you tolerate chemotherapy, specifically by looking at your chemotherapy relative dose intensity (how much chemotherapy you receive compared to the planned amount). The study aims to enroll 219 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 219 participants. It is designed to compare the effects of aerobic exercise training with progressive stretching.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, chemotherapy relative dose intensity, is measured at 12 or 24 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05773144

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

Recruiting
NAAges 18+InterventionalSupportive care
AdventHealth Translational Research Institute
~219 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:Aerobic exerciseProgressive stretching

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Chemotherapy Relative Dose Intensity
Measured over 12- or 24-weeks

Conditions

Colonic Neoplasms

Explore related trials

Colon Carcinoma

Where it's being run

3 sites across 3 states
California1
Florida1
Massachusetts1

Study leadership

  • Justin C. Brown, Ph.D. · PRINCIPAL_INVESTIGATOR · AdventHealth
  • Jeffrey A. Meyerhardt, M.D., M.P.H. · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute
  • Bette J. Caan, Dr.P.H. · PRINCIPAL_INVESTIGATOR · Kaiser Permanente

Who to contact

Justin C. Brown, Ph.D.
[email protected]
4076095000
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥18 years
Histologically confirmed stage II or III colon cancer
Completed surgical resection with curative intent
Plan to initiate chemotherapy
Engage in \<60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise
No planned major surgery during the study period
Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
Can walk 400 meters
Can read and speak English
Ability to provide written informed consent
Provide written approval by qualified healthcare professional
Willing to be randomized

Exclusion

Evidence of metastatic colon cancer
Concurrently actively treated other (non-colon) cancer
Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
Currently participating in another study with competing outcomes
Any other condition that, in the opinion of the investigator, would preclude participation or successful compliance with the protocol
Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol

What this trial measures

  • Chemotherapy Relative Dose Intensity12- or 24-weeks

    The ratio of the delivered dose intensity to the standard or planned dose intensity.