Postpyloric Feedings for Preterm Infants with Bronchopulmonary Dysplasia
This study is looking at whether a different way of feeding preterm (early-born) infants can improve their lung health. Many preterm infants develop a lung condition called Bronchopulmonary Dysplasia (BPD) and often need feeding tubes. Sometimes, feeding into the stomach (Gastric Feeds) can cause reflux and make lung problems worse. This study compares Gastric Feeds, given through a tube into the stomach, with Jejunal Feeds, given through a tube that goes past the stomach into the small intestine. Researchers want to see if Jejunal Feeds can help reduce lung problems. Infants born before 32 weeks of pregnancy who are 34-44 weeks old (post-menstrual age) and still need breathing support can join. The study will measure changes in breathing severity and analyze samples from the windpipe over 15 days. The study is currently unclear on its recruitment status and plans to enroll 50 infants.
- Study design
- This is an interventional, randomized controlled crossover trial. It plans to enroll 50 participants.
- What's involved
- Participants will receive nutrition through either a nasogastric tube or a nasojejunal tube. They will be monitored over a 15-day period during their study participation.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured over a 15-day period during study participation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants
At a glance
Conditions
NCT05777512
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Boston Children's Hospital
Boston, Massachusettsstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jonathan Levin, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in modified respiratory severity score (mRSS)Over a 15 day period during study participation
mRSS is a validated measurement for respiratory severity in chronic lung disease in neonates.
- Tracheal AspiratesOver a 15 day period during study participation.
For infants who remain on invasive respiratory support, the study team will collect tracheal aspirates for the measurement of bile acid and pepsin concentration.