Postpyloric Feedings for Preterm Infants with Bronchopulmonary Dysplasia

This study is looking at whether a different way of feeding preterm (early-born) infants can improve their lung health. Many preterm infants develop a lung condition called Bronchopulmonary Dysplasia (BPD) and often need feeding tubes. Sometimes, feeding into the stomach (Gastric Feeds) can cause reflux and make lung problems worse. This study compares Gastric Feeds, given through a tube into the stomach, with Jejunal Feeds, given through a tube that goes past the stomach into the small intestine. Researchers want to see if Jejunal Feeds can help reduce lung problems. Infants born before 32 weeks of pregnancy who are 34-44 weeks old (post-menstrual age) and still need breathing support can join. The study will measure changes in breathing severity and analyze samples from the windpipe over 15 days. The study is currently unclear on its recruitment status and plans to enroll 50 infants.

Study design
This is an interventional, randomized controlled crossover trial. It plans to enroll 50 participants.
What's involved
Participants will receive nutrition through either a nasogastric tube or a nasojejunal tube. They will be monitored over a 15-day period during their study participation.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured over a 15-day period during study participation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05777512

Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants

Recruiting
NAAges 0–1InterventionalSupportive care
Boston Children's Hospital
~50 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Gastric FeedsJejunal Feeds

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in modified respiratory severity score (mRSS)
Measured over Over a 15 day period during study participation
+1 more outcome measured
Bronchopulmonary Dysplasia

NCT05777512

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Boston Children's Hospital

    Boston, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jonathan Levin, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital

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  • Change in modified respiratory severity score (mRSS)Over a 15 day period during study participation

    mRSS is a validated measurement for respiratory severity in chronic lung disease in neonates.

  • Tracheal AspiratesOver a 15 day period during study participation.

    For infants who remain on invasive respiratory support, the study team will collect tracheal aspirates for the measurement of bile acid and pepsin concentration.