A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
{ "A Study of AC676 for Relapsed/Refractory B-Cell Malignancies", "This study is testing a new oral drug called AC676 for people with B-cell malignancies (cancers of certain white blood cells) that have returned or not responded to previous treatments. The main goals are to find a safe dose of AC676, understand its side effects, and see how well it works. AC676 works by targeting a specific protein called BTK, which is involved in the growth of these cancer cells. You may be able to join if you are at least 18 years old and have a confirmed diagnosis of certain types of relapsed/refractory B-cell lymphomas or leukemia. The study aims to enroll about 60 participants.", "design": "This is a Phase 1, first-in-human study where all participants will receive AC676. It is an open-label study, meaning both you and your doctors will know you are receiving the study drug.", "commitments": "AC676 will be taken by mouth in 28-day cycles. The study will monitor for side effects and laboratory changes for approximately 18 months.", "compensation": "Not stated in the trial record.", "follow_up": "The study will track side effects and laboratory changes for approximately 18 months after treatment begins.", }
- Study design
- Not specified.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
At a glance
Conditions
Where it's being run
9 sites across 8 statesWho to contact
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Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Incidence of dose limiting toxicities (DLTs) from AC676 monotherapyFrom cycle 1 day 1 to Cycle 1 day 28. Cycles are 28 days.
- Incidence of treatment-emergent adverse events (TEAEs) and clinically significant Grade 3 or higher laboratory abnormalities using CTCAE v5.0 criteria.Approximately 18 months
- Maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D)Approximately 18 months