NCT05787639

Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)

Active, Not Recruiting
PHASE2Ages 18+InterventionalTreatment
University of California, San Diego
~28 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Evorpacept

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pathologic complete response
Measured over week 7-10
+1 more outcome measured
Oropharynx Cancer

NCT05787639

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Oregon Health and Science University

    Portland, Oregonno site contact published

  • Providence Health & Services

    Portland, Oregonno site contact published

  • UC San Diego Moores Cancer Center

    La Jolla, Californiano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jospeh A Califano, MD · PRINCIPAL_INVESTIGATOR · University of California, San Diego

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Histologically confirmed diagnosis of Stage I T1-2N1M0 HPVOPC (Human Papilloma Virus Oropharynx Cancer)
Amenable to surgical resection
Are able to safely receive neoadjuvant radiation and Evorpacept/Pembrolizumab
  • Pathologic complete responseweek 7-10

    Pathologic response is determined when surgery is performed at week 7-10 of study

  • Major pathologic responseweek 7-10

    Major pathologic response is defined as \<10% viable tumor cells in the resection specimen) after surgical resection