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TrIGR for PTSD in Veterans

This study is looking at two behavioral therapies for posttraumatic stress disorder (PTSD) in U.S. Veterans. It compares Trauma Informed Guilt Reduction Therapy (TrIGR), which focuses on reducing guilt and shame, with Cognitive Processing Therapy (CPT), a common PTSD treatment. Researchers want to see if TrIGR is just as effective as CPT in reducing PTSD symptoms. You might be able to join if you are a U.S. Veteran aged 18 or older, have PTSD or similar symptoms, and experience significant trauma-related guilt. The main way success will be measured is by looking at changes in your PTSD symptoms over 28 weeks. The current recruitment status is unclear.

Study design
This study plans to enroll 160 Veterans and will randomly assign them to receive either TrIGR or CPT.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be measured from the start of the study until 28 weeks later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05789329

Non-Inferiority Trial of TrIGR for PTSD

Active, Not Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~160 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Trauma Informed Guilt Reduction TherapyCognitive Processing Therapy

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
change in Clinician Administered PTSD Scale - 5 (CAPS-5)
Measured over baseline to 28 weeks later

Conditions

PTSD

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

2 sites across 2 states
California1
Florida1

Study leadership

  • Sonya B. Norman, PhD · PRINCIPAL_INVESTIGATOR · VA San Diego Healthcare System, San Diego, CA

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

U.S. Veterans age 18 or older;
meets diagnostic criteria for PTSD or subthreshold PTSD;
a score of 2 or higher ("true" to "extremely true") on feeling trauma-related guilt much or all of the time or scoring 3 or higher ("very true" or "extremely true") on at least one guilt cognition factor (hindsight bias/responsibility, wrongdoing, or lack of justification) on the Trauma Related Guilt Inventor.
not currently receiving trauma-focused treatment such as CPT or PE; and
willingness to attend psychotherapy and assessment sessions.

Exclusion

Impaired mental status as measured by the Montreal Cognitive Assessment (MoCA) (score \< 21) and confirmed by a neuropsychologist,
Veterans with significant current risk of suicidal/homicidal behavior will be referred to more appropriate treatment;
Current severe substance use disorder (in the past two months) based on DSM-5 criteria;
Current unmanaged psychosis or mania;
life threatening or unstable medical illness; or
inability to read.

What this trial measures

  • change in Clinician Administered PTSD Scale - 5 (CAPS-5)baseline to 28 weeks later

    Clinician Administered PTSD Scale - 5 (CAPS-5) - score range 0 - 80; higher scores are indicative of more severe PTSD symptoms. Reduction in scores is considered a positive outcome.