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Aerobic Exercise for Colorectal Cancer Survivors

This study is looking at how aerobic exercise training affects body fat between muscles (intermuscular adipose tissue) in people who have had colorectal cancer. You may be able to join if you are 18 or older, have been diagnosed with stage I, II, or III colon or rectal cancer, and have completed surgery and other cancer treatments. You should also be exercising less than 150 minutes per week and be ready to start exercising. The main goal is to see changes in whole-body intermuscular adipose tissue up to 12 weeks. The study is currently unclear about its status and plans to enroll 70 participants.

Study design
This is an interventional study, meaning participants will receive specific interventions. It plans to enroll 70 participants.
What's involved
Participants will engage in either moderate- to vigorous-intensity aerobic exercise or progressive stretching of eight major muscle groups.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, whole-body intermuscular adipose tissue, is measured up to Week 12.

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NCT05789433

Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Recruiting
NAAges 18+InterventionalSupportive care
AdventHealth Translational Research Institute
~70 participants
Updated 2025-07-03 on ClinicalTrials.gov
What's tested:Aerobic exerciseProgressive stretching

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Whole-Body Intermuscular Adipose Tissue
Measured over up to Week 12

Conditions

Colonic Neoplasms
Rectal Neoplasms

Explore related trials

Colorectal Carcinoma

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Justin C. Brown, Ph.D. · PRINCIPAL_INVESTIGATOR · AdventHealth

Who to contact

Justin C. Brown, Ph.D.
[email protected]
407-303-5600
Email the study team

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Eligibility criteria

Inclusion

Age ≥18 years
Histologically confirmed stage I, II, or III colon or rectal cancer
Completed surgical resection with curative intent
Completed other cancer-directed treatments
Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
No planned major surgery during the study period
Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
Ability to provide written informed consent
Provide written approval by a qualified healthcare professional
Willing to be randomized

Exclusion

Evidence of metastatic or recurrent colorectal cancer
Concurrently actively treated other (non-colorectal) cancer
Scheduled to receive other postoperative cancer-directed treatment(s)
Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
Currently participating in another study with competing outcomes
Contraindications to magnetic resonance imaging
Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol

What this trial measures

  • Whole-Body Intermuscular Adipose Tissueup to Week 12

    Mean (kg) whole-body intermuscular adipose tissue quantified using magnetic resonance imaging.