Exercise for Gastrointestinal Cancer Treatment Side Effects

This study is looking at how different amounts of structured treadmill walking (90, 150, or 300 minutes per week) can help reduce side effects from treatment for gastrointestinal (GI) cancers. Researchers want to find out which amount of exercise is practical, safe, and has positive effects on your body. They will also see if exercise changes how well you can stick to your cancer treatment plan, including whether you need to stop, delay, or reduce your treatment, or take extra medicine for side effects. You may be able to join if you are 18 or older, have colorectal or esophago/gastric solid tumors, and are about to start chemotherapy. The study aims to see if participants can receive at least 90% of their planned treatment dose, measured over 5 years.

Study design
This is an interventional study with a planned enrollment of 216 participants. It will test three different amounts of structured treadmill walking.
What's involved
You will participate in individualized walking up to 7 times per week throughout your cancer treatment. Study staff will help you access a treadmill, either at home or at a local fitness facility.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at 5 years, suggesting a long-term follow-up period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05789485

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Recruiting
PHASE2Ages 18+InterventionalSupportive care
Memorial Sloan Kettering Cancer Center
~216 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:structured treadmill walking

At a glance

Recruiting sites
8 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
proportion of patients achieving (ratio of delivered to planned treatment) RDI ≥ 90%
Measured over 5 years
Gastrointestinal Cancer

NCT05789485

Where you'd take part

This study runs at 8 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Hartford Healthcare Alliance (Data Collection Only)

    Hartford, Connecticutstudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jerseystudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jerseystudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    New York, New Yorkstudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jerseystudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Rockville Centre, New Yorkstudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)

    Commack, New Yorkstudy coordinator listed

    Recruiting

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jessica Scott, PhD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

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Eligibility criteria

Inclusion

Aged ≥18 years
Diagnosed with colorectal or esophago/gastric solid tumors as defined by one of the following:
Histological confirmation
As per standard of care imaging
Scheduled to receive neoadjuvant chemotherapy or chemotherapy for newly diagnosed metastatic disease
Performing ≤90 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report
Willingness to comply with all study-related procedures
Cleared for exercise participation as per screening clearance via the Physical Activity Readiness Questionnaire

Exclusion

Enrollment onto any other lifestyle interventional investigational study, except interventions determined by the PI not to confound study outcomes
Receiving treatment for any other diagnosis of invasive cancer
Mental impairment leading to inability to cooperate
Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
  • proportion of patients achieving (ratio of delivered to planned treatment) RDI ≥ 90%5 years

    RDI (%) will be calculated as the ratio of delivered to planned dose intensity (delivered dose intensity/planned dose intensity).