Take A Break - Rural Study for Smoking Cessation

This study, called "Take a Break - Rural," is testing new ways to help people in rural areas who smoke but aren't quite ready to quit. It compares two approaches: one uses a program called "Take a Break" along with Nicotine Replacement Therapy (NRT) samples, and the other uses NRT samples alone. The "Take a Break" program encourages you to try being smoke-free for two weeks. The study wants to see how many people get involved and if these programs help people stop smoking after 6 months. To join, you need to be at least 18, speak English, be able to get texts, and currently smoke but not be actively trying to quit within the next 30 days. The study plans to enroll 800 participants.

Study design
This is an interventional study with an unclear phase, planning to enroll 800 participants. It compares two behavioral interventions: "Take a Break plus Nicotine replacement therapy (NRT) Sampling" and a "Comparison" group receiving NRT sampling only.
What's involved
The main element of the "Take a Break" intervention is a two-week challenge where you report days you are smoke-free, preceded by a 1-week training challenge.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for smoking cessation at 6 months after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05790486

Take A Break - Rural

Recruiting
NAAges 18+InterventionalPrevention
Wake Forest University Health Sciences
~800 participants
Updated 2026-02-11 on ClinicalTrials.gov
What's tested:Take a Break plus Nicotine replacement therapy (NRT) SamplingThe ComparisonCommunity Paramedicine Standard Plus Enhanced Implementation ProgramCommunity Paramedicine Standard Implementation Program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants engaged
Measured over Monthly from initial training to end of referral period year 1 to year 4 longitudinally
+1 more outcome measured
Smoking
Smoking Behaviors
Smoking Cessation
1 sites across 1 states
North Carolina1
  • Thomas K Houston, MD, MPH · PRINCIPAL_INVESTIGATOR · Wake Forest University Health Sciences
  • Rajani Sadasivam, PhD · PRINCIPAL_INVESTIGATOR · UMass Chan Medical School

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Current Smoker
at least 18 years old
speaks English
Able to receive texts and read text (literate)
Have a text-enabled phone or receive one from the study team
Not yet ready to quit smoking

Exclusion

actively quitting smoking
preparing to quit smoking within 30 days
prisoners
FDA- defined NRT contraindications
unable or unwilling to provide informed consent
  • Number of participants engagedMonthly from initial training to end of referral period year 1 to year 4 longitudinally

    Referral rate of participants by EMS personnel

  • Follow-up smoking cessation6 months

    Point prevalent cessation is measured by the number of participants with a decreased carbon monoxide level as verified by carbon monoxide levels in blood.