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Transcranial Focused Ultrasound Study for Healthy Individuals

This study is testing a device called Focused Ultrasound Stimulation (tFUS) to understand how it affects brain activity. Researchers want to see if different settings of tFUS can either increase or decrease brain signals called Motor Evoked Potentials (MEPs). You might be able to join if you are a healthy adult between 18 and 55 years old, have no history of mental or physical illness, and speak English. The main goal is to measure changes in MEPs right after the stimulation. The study is currently unclear on its recruitment status and plans to enroll 25 participants.

Study design
This is an interventional study with an unclear phase, planning to enroll 25 healthy participants.
What's involved
You would undergo tFUS and MRI scans. The specific number of visits or duration of participation is not detailed.
Compensation
Not stated in the trial record.
Follow-up
Motor Evoked Potential Amplitude is measured immediately post-stimulation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05792020

Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

Not Yet Recruiting
NAAges 18–55InterventionalBasic science
Medical University of South Carolina
~25 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Focused Ultrasound Stimulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor Evoked Potential Amplitude
Measured over Immediate Post-Stimulation

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
South Carolina1

Who to contact

Lisa M McTeague, Ph.D.
[email protected]
8437928274
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female
Age 18-55
Endorse good health with no history of mental or physical illness or implanted metal
English as a primary language
Capacity to consent
Negative urine pregnancy test if a female of childbearing potential
Willingness to adhere to the tFUS and MRI study schedule

Exclusion

Any psychotropic medication is taken within 5 half-lives of procedure time
Any head trauma resulting in loss of consciousness
Personal or family history of neurological illness or injury
Alcohol or substance abuse or dependence (other than tobacco) in the past week
Diagnosis or current treatment (pharmacological or otherwise) of any psychiatric condition
Pregnancy
Personal or family history of seizures or epilepsy
Claustrophobia or inability to stay still in the MR scanner environment
Any metal in the body
Other contraindications to electrical or electromagnetic stimulation
Hair in dreadlocks, braids, or weave
Diagnosis of COVID-19 in the past 14 days
Inability to adhere to the treatment schedule.

What this trial measures

  • Motor Evoked Potential AmplitudeImmediate Post-Stimulation

    How has the focused ultrasound stimulation affected MEP amplitude