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Comparing Treatments for Distal Femur Fractures

This study is comparing two surgical treatments for fractures in the lower part of the thigh bone (distal femur fractures), especially those that happen around a knee replacement. The two treatments are Open Reduction and Internal Fixation (ORIF), which uses plates and screws to fix the bone, and Distal Femur Replacement (DFR), which involves replacing the end of the thigh bone and the knee joint. Researchers want to see which treatment leads to better recovery and knee function. You may be able to join if you are 55 to 100 years old, speak English, and have a specific type of distal femur fracture that needs surgery. The study will measure success by looking at your mobility (Timed Up and Go Test) and how you feel about your knee's health and function (KOOS Jr assessment). The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 100 participants. It will compare outcomes between two surgical approaches for distal femur fractures.
What's involved
Participants will undergo either ORIF or DFR surgery. They will then complete mobility tests and questionnaires to assess their knee function and health.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 2 years after their surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05792189

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

Recruiting
NAAges 55+InterventionalTreatment
University of Florida
~100 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Timed Up and Go Test on subjects with ORIF of distal femur fracturesKoos Jr assesment on subjects with ORIF of distal femur fracturesTimed Up and Go Test on subjects with DFR of distal femur fractureKoos Jr assesment on subjects with DFR of distal femur fracture

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Open reduction and internal fixation (ORIF) of distal femur fracture
Measured over Up to 2 years

Conditions

Distal Femur Fracture

Explore related trials

Femoral Fractures, Distal

NCT05792189

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UF & Shands Orthopaedics and Sports Medicine Institute

    Gainesville, Floridano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Matthew Patrick, MD
[email protected]
352-273-7188
Email the study team

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Eligibility criteria

Inclusion

English speaking patients
55 years or older with Su Type II or Su Type III periprosthetic femur fractures or OTA/OA 33C or 338/3 native knee distal femur fracturing requiring surgical intervention and are medically fit to undergo surgical intervention

Exclusion

Patients with an active total knee prosthetic infection
Patients unable to undergo surgical intervention
Patient with an open fracture
Non-English-speaking patients
Oncologic/pathologic fracture
Poly-trauma patient (or other associated major orthopaedic injuries)

What this trial measures

  • Open reduction and internal fixation (ORIF) of distal femur fractureUp to 2 years

    Subjects will perform the Timed Up and Go Test, This test is used to assess mobility. Subjects are asked to wear regular footwear and can use their walking device as needed. Subjects begin by sitting in a standard armchair. Next participants are instructed to walk 10 feet to a designated line at a normal pace. Once they reach the line they are to turn and walk back to the chair and sit down. The test starts on the study staff go signal and ends once the subject is fully seated in the chair.