Hypoparathyroidism Natural History Study

This is an observational study for adults with hypoparathyroidism (HPT), a condition where your body doesn't make enough parathyroid hormone. The study aims to understand how HPT affects different organs over three years. Researchers will monitor your kidney function at several points to see how the disease progresses. This study is not testing a new treatment, but rather observing the natural course of HPT to better understand its long-term effects. Anyone aged 18 to 100 with HPT can participate if they are willing and able to follow study procedures. The study is currently unclear on its recruitment status.

Study design: This is an observational study involving 106 adult participants with hypoparathyroidism.
What's involved: You would have your kidney function measured at baseline, 6, 12, 18, 24, 30, and 36 months.
Compensation: Not stated in the trial record.
Follow-up: You would be followed for 36 months after joining the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Hypoparathyroidism Natural History Study

Recruiting

Not specifiedAges 18+Observational

Columbia University

~106 participants

Updated 2025-12-16 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Kidney function

Measured over baseline, 6, 12, 18, 24, 30, 36 Months

Conditions

Hypoparathyroidism

Where it's being run

1 sites across 1 states

New York1

Study leadership

Mishaela Rubin, MD · PRINCIPAL_INVESTIGATOR · Columbia University

Who to contact

Noelle Texeira

[email protected]

212-305-2801

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

An understanding, ability and willingness to fully comply with study procedures and restrictions.

Ability to voluntarily provide written, signed and dated informed consent as applicable to participate in the study.

Male or female ≥18 years of age with HPT. All HPT sub-types are eligible, including surgical (HPT-S) and nonsurgical (HPT-NS) HPT: autoimmune, genetic (including but not limited to: DiGeorge syndrome, autoimmune polyendocrine syndrome type 1, hypoparathyroidism sensorineural deafness and renal disease syndrome, Kearns-Sayre syndrome, mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes \[MELAS\] syndrome, mitochondrial trifunctional protein \[MTP\] deficiency syndrome, Kenny-Caffey syndrome, Sanjad-Sakati syndrome, autosomal dominant hypocalcemia), infiltrative (granulomatous), mineral deposition (copper, iron), metastatic, radiation and idiopathic HPT.

Diagnosis of HPT established based on historic hypocalcemia in the setting of inappropriately low serum PTH levels on two occasions.

All treatment regimens are permitted, including but not limited to conventional management with calcium (e.g. calcium citrate, calcium carbonate, etc), active vitamin D (calcitriol, alfacalcidol), parent vitamin D, magnesium, phosphate binders and thiazides. Use of PTH-like drugs are permitted.

Exclusion

Functional HPT

Transient HPT

Pseudohypoparathyroidism

Pregnancy

What this trial measures

Kidney functionbaseline, 6, 12, 18, 24, 30, 36 Months
blood test for changes in eGFR (in mL/min/1.73m\^2)

Trialytics