Sleep and Cognition in Focal Epilepsy Study

This study is looking at how sleep patterns affect thinking and memory in people with focal epilepsy. We want to see if playing sounds (Acoustic Stimulation) during sleep can improve sleep and cognitive abilities. We'll compare this to not playing sounds (SHAM Stimulation). You could join if you are 18-40 years old, have focal epilepsy, and don't have other major neurological problems or severe sleep apnea. We'll measure your sleepiness and sleep quality at the start, and then again a week after your overnight stays. The study aims to understand the connection between sleep and brain function in epilepsy, hoping to develop better treatments in the future. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 40 participants. It will compare Acoustic Stimulation to SHAM Stimulation during sleep monitoring.
What's involved
You will wear a device to track activity for one week and a home sleep study device for one night. You will also have two overnight stays at a sleep center, where you'll have EEG leads placed and do cognitive tests before and after sleep.
Compensation
Not stated in the trial record.
Follow-up
Your sleepiness will be measured over one week after your overnight stays.

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NCT05794295

Sleep Architecture & Cognition in Focal Epilepsy

Recruiting
NAAges 18–40Interventional
University of California, Davis
~40 participants
Updated 2026-08-07 on ClinicalTrials.gov
What's tested:Acoustic Stimulation (AS)SHAM Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Stanford Sleepiness Scale
Measured over participant completes over one week post EMU stay
+4 more outcomes measured
Focal Epilepsy
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Age 18 - 40 years of age
Focal Epilepsy
Capacity to fully cooperate and follow directions
no other significant neurological disorders which could affect cognition

Exclusion

Current use of any medications that can significantly affect cognition
No severe sleep apnea
  • Stanford Sleepiness Scaleparticipant completes over one week post EMU stay

    Alertness Test; charts how alert a participant feels for up to 18 hours of the day for 7 days; scale is from 1-7 with higher scores meaning more sleepiness; abnormal is 4 and above

  • Pittsburgh Sleep Quality Index (PSQI)screening

    used to measure quality and patterns of sleep in adults

  • Epworth Sleepiness Scalescreening

    subjective measure of a patient's sleepiness; scores are from 0-24 with higher scores meaning more sleepiness; abnormal is 10 and above

  • Karolinska Sleepiness Scale / Sleep Diaryscreening

    Self-administered indication of sleepiness; scores are from 1-9 with higher scores meaning more sleepiness; abnormal is 7 and above

  • Vigor Affect Visual Analog Scalescreening

    self-administered assessment of mood; scores are from 0-10; depending on the question, higher score can mean more sleepiness or less sleepiness