This study is looking at how stress affects thinking and memory in people with mild cognitive impairment (MCI), a condition that can sometimes lead to Alzheimer's disease. Researchers will use a behavioral intervention called the Trier Social Stress Test (a public speaking and mental arithmetic task) to create acute stress. They want to see if your body's hormone response to stress and your genes linked to Alzheimer's disease predict how much your memory and executive function (planning, problem-solving) change after stress, and over two years. The study aims to enroll 240 participants aged 60 and older who have MCI. Success would mean understanding how stress vulnerability might help identify people who could benefit from specific Alzheimer's treatments. The current recruitment status is unclear.

Study design

This is an interventional study planning to enroll 240 participants. It is not specified if it is randomized or blinded.

What's involved

You would have three in-person study visits. These visits will involve undergoing the Trier Social Stress Test and completing a battery of cognitive tests.

Compensation

Not stated in the trial record.

Follow-up

Your memory and executive function will be measured at baseline, up to 1 month later, and up to 2 years later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.