A Study of RO7656594 for Advanced or Metastatic Prostate Cancer

This study is testing a new oral medication called RO7656594 for men with advanced or metastatic prostate cancer. Researchers want to understand how safe RO7656594 is, how your body handles it (pharmacokinetics), and if it shows any signs of working against the cancer. They also aim to find the best dose for future studies. You may be able to join if you have metastatic prostate cancer that has already been treated with certain hormone therapies (like abiraterone or enzalutamide). The study will look at side effects and any dose-limiting toxicities (serious side effects that prevent further treatment) to determine its success.

Study design
This is an interventional study planning to enroll 210 men. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
You will be monitored for adverse events from the start of treatment until 28 days after your last dose, for up to approximately 24 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05800665

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
Genentech, Inc.
~210 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:RO7656594

At a glance

Recruiting sites
26 of 26 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Participants with Adverse Events
Measured over From Cycle 1 Day 1 until 28 days after the final dose (Up to approximately 24 months) (1 cycle= 28 days)
+1 more outcome measured
Advanced Prostate Cancer
Metastatic Prostate Cancer
26 sites across 15 states
South Korea4
United Kingdom4
Spain3
New South Wales2
Victoria2
France2
Arizona1
Connecticut1
  • Clinical Trials · STUDY_DIRECTOR · Genentech, Inc.
GO44537 https://forpatients.roche.com/ No attachments to email below.
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  • Percentage of Participants with Adverse EventsFrom Cycle 1 Day 1 until 28 days after the final dose (Up to approximately 24 months) (1 cycle= 28 days)
  • Percentage of Participants Who Experience Dose-limiting Toxicities (DLTs)Days 1-28 of Cycle 1