Eating to Adjust the Timing System

This study is looking at how different ways of eating (dietary interventions) affect your body's natural rhythms, like when you feel hungry or how your body uses energy. Researchers want to understand if changing what you eat can influence these internal clocks. They will measure your melatonin rhythm (a hormone that helps with sleep) and how much of your daily food intake happens in the evening. You might be able to join if you are between 18 and 45 years old, have a healthy body mass index (BMI) between 18.5 and 29.9, and don't have serious medical conditions or use most medications. The study aims to enroll 24 participants, but its current recruitment status is unclear.

Study design
This study will involve 24 participants who will be assigned to two different dietary conditions. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
You will complete two dietary interventions, be provided with standard meals, record your daily food intake, and have two inpatient stays. You will also have frequent blood draws and provide urine, saliva, and stool samples.
Compensation
Not stated in the trial record.
Follow-up
The study measures the circadian phase of melatonin rhythm at Days 18-19 and the percentage of daily caloric intake in the biological evening at Days 8-14.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05800990

Eating to Adjust the Timing System

Recruiting
NAAges 18–45InterventionalBasic science
Brigham and Women's Hospital
~24 participants
Updated 2025-09-29 on ClinicalTrials.gov
What's tested:dietary intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Circadian phase of melatonin rhythm
Measured over Days 18-19
+1 more outcome measured
Dietary Intervention

NCT05800990

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Brigham and Women's Hospital

    Boston, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Frank AJL Scheer, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

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Eligibility criteria

Inclusion

18-45 yr old
BMI 18.5-29.9
No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
Without medication use (except oral contraceptives)

Exclusion

Currently smoking/vaping or 5 or more years of smoking/vaping
History of drug or alcohol dependency
History of psychiatric illness or disorder
People with food allergies/intolerances or following specific diets
  • Circadian phase of melatonin rhythmDays 18-19

    Hourly plasma melatonin will be measured under the Constant Routine condition

  • Percentage of daily caloric intake in the biological eveningDays 8-14

    Percentage of caloric intake within the 4 hours before bedtime will be derived from real-time record of food and beverage intake during the intervention period