Metabolic Adaptations to Weight Loss With and Without Exercise
This study is looking at how your body changes when you lose weight, specifically comparing weight loss with exercise to weight loss without exercise. Researchers want to understand how adding exercise to a weight loss program affects your metabolic health (how your body uses energy) and fat tissue. You might be able to join if you are between 18 and 40 years old, have a Body Mass Index (BMI) between 30 and 40 kg/m2 (which indicates obesity), and don't regularly exercise. The study will measure things like insulin sensitivity (how well your body uses insulin to control blood sugar) and fatty acid turnover (how your body processes fats) to see how these different approaches to weight loss impact your body. The study is currently recruiting 68 participants.
- Study design
- This is an interventional study that will enroll 68 participants. Participants will be randomly assigned to either a moderate intensity continuous exercise group or a group that remains sedentary.
- What's involved
- Participants in the exercise group will complete moderate intensity continuous exercise 4 days per week. The study will measure insulin sensitivity and fatty acid turnover at 2 hours, and adipose tissue capillarization (blood vessel formation in fat tissue) at 30 minutes.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for measurements taken at 30 minutes and 2 hours after certain procedures.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Metabolic Adaptations to Weight Loss With and Without Exercise
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jeffrey Horowitz, PhD · PRINCIPAL_INVESTIGATOR · University of Michigan
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Insulin sensitivity2 hours
a hyperinsulinemic-euglycemic clamp will be used to quantify peripheral insulin sensitivity
- Fatty acid turnover2 hours
stable isotope tracer infusion methods will be used to assess fatty acid turnover
- Adipose tissue capillarization30 minutes
measured immunohistochemically using an antibody for CD31, quantified using ImageJ software
- Adipose tissue fibrosis30 minutes
measured histologically using Sirus Red Staining, quantified using ImageJ software