This study is looking at how small blood vessels respond to intense exercise in older adults (ages 65-85) and if a simple method called ischemic conditioning can protect these vessels. Ischemic conditioning involves briefly restricting blood flow to an arm using a blood pressure cuff. The study aims to see if this intervention can make your blood vessels more resilient to stress. Success will be measured by changes in how well your blood vessels widen (Acetylcholine-mediated dilation) and the density of perfused vessels after exercise. You cannot participate if you have had a heart attack recently, severe obesity, heart failure, uncontrolled high blood pressure, or other conditions that prevent high-intensity exercise or arm compression. The current status of this study is unclear.

Study design

This interventional study plans to enroll 60 participants who will be randomly assigned to either a Low or High Ischemic Conditioning group. The study design is randomized block.

What's involved

You will have 3 study visits. During these visits, you will undergo assessments for frailty and physical function, perform exercise tests, and have microvascular assessments. You will also take home a blood pressure cuff for home-based ischemic conditioning.

Compensation

Not stated in the trial record.

Follow-up

Changes in microvascular function will be measured at 0.5 hours and 2 hours after certain procedures.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.