Cortical Correlates of Gait in Parkinson's Disease

This study is looking at how two types of tactile cueing (a system that gives you touch-based signals) might help people with Parkinson's disease walk more easily. Researchers want to see if personalized tactile cueing or fixed tactile cueing can make walking more automatic, meaning it requires less conscious effort. They will measure brain activity in the prefrontal cortex (the part of your brain involved in planning and complex thinking) and parietal cortex (involved in processing sensory information), as well as how steady your steps are. You might be able to join if you are 45-85 years old and have been diagnosed with Parkinson's disease by a movement disorders neurologist. The study aims to enroll 60 participants, but its current recruitment status is unclear.

Study design
This study will involve 60 participants with Parkinson's disease. You will be randomly assigned to receive either personalized tactile cueing or fixed tactile cueing.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Brain activity and stride variability will be measured on day 1.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05818189

Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing

Recruiting
NAAges 45–85InterventionalTreatment
Oregon Health and Science University
~60 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:Personalized tactile cueingFixed tactile cueing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prefrontal cortex activity
Measured over day 1
+5 more outcomes measured
Parkinson Disease

NCT05818189

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Oregon Health and Science University

    Portland, Oregonstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Martina Mancini, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Diagnosis of idiopathic Parkinson's Disease from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with 1 or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions
Without musculoskeletal or peripheral or central nervous system disorders (other than PD) that could significantly affect their balance and gait
All subjects will be capable of following directions for the protocols and to give informed consent.
Hoehn \& Yahr Levels II-III.

Exclusion

Severe dyskinesia that may affect quality of fNIRS.
Major musculoskeletal or neurological disorders, structural brain disease, epilepsy, acute illness or health history, other than Parkinson's Disease, significantly affecting gait and turning i.e., peripheral neuropathy with proprioceptive deficits (detected as lack of toe proprioception assessed during the neurological exam at Day 1), musculoskeletal disorders, vestibular problem, head injury, stroke.
Montreal cognitive assessment (MoCA) score \< 21 or dementia that precludes consent to participate or ability to follow testing procedures
Inability to stand or walk for 2 minutes without an assistive device.
  • Prefrontal cortex activityday 1

    Oxygenated hemoglobin over the prefrontal cortex measures by fNIRS

  • Parietal cortex activityday 1

    Oxygenated hemoglobin over the parietal cortex measures by fNIRS

  • Stride time variabilityday 1

    Variability of stride time during 2 minute walking

  • Local Dynamic Stabilityday 1

    Stability during gait is assessed by phase dependent local dynamic stability (LDS) measures of the trunk acceleration while walking

  • Turn durationday 1

    Average duration of 360 turning while performing a 1 minute turning in place task

  • Turn jerkday 1

    Average turning smoothness while performing a 1 minute turning in place task