Semaglutide for PCOS and Ovulation
This study is looking at how Semaglutide (known as Wegovy or Ozempic) might help girls and women aged 12-35 with Polycystic Ovary Syndrome (PCOS) and obesity. PCOS is a common hormone problem that can affect ovulation (when an egg is released). Participants will take Semaglutide injections for 10 months, with the dose gradually increased as recommended. Researchers want to see if this treatment can improve how often ovulation happens. They will compare ovulation frequency before and after taking Semaglutide. The study aims to enroll 80 participants and is currently recruiting.
- Study design
- This is an interventional study involving 80 participants. It is not specified if it is randomized or blinded.
- What's involved
- Participants will have a 4-month observation period, followed by 10 months of Semaglutide injections with dose increases. Ovulation frequency will be measured at 14 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Ovulation frequency will be measured at 14 months, which is 4 months after the 10-month treatment period ends.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
At a glance
Conditions
NCT05819853
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Colorado Anschutz/Children's Hospital Colorado Aurora
Aurora, Coloradostudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Melanie Cree-Green, MD,PhD · PRINCIPAL_INVESTIGATOR · University of Colorado Anschutz/Children's Hospital Colorado
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in ovulation frequency before and after semaglutide in females with PCOS14 months
The change in ovulation will be measured at baseline and 6-10 months post treatment with semaglutide from 4 months daily urinary progesterone metabolites