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Cognitive Decline After Deep Brain Stimulation for Parkinson's Disease

This study looks at how Deep Brain Stimulation (DBS) affects thinking and memory in people with Parkinson's Disease. Researchers want to find brain markers using MRI scans that can predict how an individual's thinking skills might change after DBS. You could join if you are an adult with Parkinson's Disease who is already planning to have DBS surgery as part of your regular medical care. The study will measure changes in your thinking abilities from about one month before your DBS surgery until one year after. The goal is to understand why some people experience a decline in thinking after DBS, even when their movement symptoms improve. This knowledge could help doctors choose the best treatment for future patients.

Study design
This is an observational study planning to enroll 80 participants. It will include people with Parkinson's Disease undergoing DBS and control participants without Parkinson's Disease.
What's involved
You would have four visits: a 1-hour screening, a 1.5-hour MRI scan before DBS, and a 3.5-hour cognitive assessment after DBS. You will also have routine pre-operative neuroimaging, including a high-resolution MRI scan.
Compensation
Not stated in the trial record.
Follow-up
Your cognition will be measured from about one month before DBS surgery until one year after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05822388

Cognitive Decline Following Deep Brain Stimulation

Recruiting
Not specifiedAges 18+Observational
Medical University of South Carolina
~80 participants
Updated 2026-05-29 on ClinicalTrials.gov
What's tested:Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Cognition
Measured over From the DBS candidacy evaluation stage (approximately one month prior to deep brain stimulation) until 1 year post surgery
+1 more outcome measured

Conditions

Parkinson Disease
Movement Disorders

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Parkinson Disease

NCT05822388

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical University of South Carolina

    Charleston, South Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Daniel H Lench, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Daniel H Lench, PhD
[email protected]
843-792-9115
Email the study team

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Eligibility criteria

Inclusion

Subjects above 18 years of age
Subjects who will undergo DBS surgery as part of their clinical care for PD
Subjects above 18 years of age
Age matched to participants in PD group

Exclusion

Uncorrected visual or hearing impairments, as indicated by self-report
Individuals who are pregnant or expect to become pregnant during the course of the study
Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
COPD with oxygen dependence
Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
Diagnosis of Parkinsons Disease or other movement disorder
Untreated neuropsychiatric disorders
Uncorrected visual or hearing impairments, as indicated by self-report
Individuals who are pregnant or expect to become pregnant during the course of the study
Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
COPD with oxygen dependence
Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

What this trial measures

  • Change in CognitionFrom the DBS candidacy evaluation stage (approximately one month prior to deep brain stimulation) until 1 year post surgery

    Change in cognitive performance using a comprehensive neuropsychological battery (e.g., language, executive control, memory, and attention)

  • Brain Microstructure (DKI)Within the DBS candidacy evaluation stage (approximately one month prior to deep brain stimulation (DBS))

    Nucleus Basalis of Meynert (NBM) and striatal microstructural integrity using diffusion kurtosis imaging (mean kurtosis; MK)