This study is looking at how a collagen peptide supplement, called SOLUGEL, might help people recovering from total knee replacement surgery (TKA) for knee osteoarthritis. Researchers want to see if taking SOLUGEL before surgery affects how your body's connective tissues heal and how well you recover. A placebo (maltodextrin, a sugar) will be compared to SOLUGEL. You might be able to join if you are 50-75 years old, have knee osteoarthritis, and are scheduled for a TKA at UAMS in Little Rock. The main goal is to measure changes in your body's genetic activity related to tissue healing two months after you start taking the supplement. The study plans to enroll 44 participants, but its current recruitment status is unclear.

Study design

This is an interventional study planning to enroll 44 participants. It compares a collagen peptide supplement (SOLUGEL) to a placebo (maltodextrin).

What's involved

You would take a dietary supplement before your total knee replacement surgery. Tissue samples (ACL, synovial fluid, bone fragments) and blood will be collected during your surgery.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured at 2 months after supplementation, which suggests follow-up for at least that long.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.