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Buprenorphine, Clonidine, and Dexamethasone for Brachial Plexus Blocks in Upper Extremity Surgery

This study is looking at whether adding buprenorphine, clonidine, and dexamethasone to a nerve block (called an Interscalene brachial plexus block) before shoulder surgery can reduce the amount of pain medication (morphine) you need afterward. You could be eligible if you are at least 18 years old, having shoulder arthroscopy, and don't have certain health conditions like severe lung disease or daily opioid use. The main goal is to see if there's a difference in morphine use 24 hours after surgery between those who receive the nerve block with these three medications and those who receive the nerve block with buprenorphine alone. The study is currently recruiting 120 participants.

Study design
This is a randomized study, meaning you would be randomly assigned to one of two groups. It is single-blinded, so you would not know which treatment you are receiving.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main outcome is measured 24 hours after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05824832

Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Recruiting
PHASE4Ages 18+InterventionalTreatment
Loyola University
~120 participants
Updated 2025-03-07 on ClinicalTrials.gov
What's tested:Interscalene block with the addition of buprenorphine, clonidine, dexamethasoneInterscalene block with buprenorphine alone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Morphine requirement post surgery
Measured over 24 hours

Conditions

Pain, Postoperative

Explore related trials

PainShoulder Surgery

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Audrice Francois, MD · PRINCIPAL_INVESTIGATOR · Loyola University Chicago

Who to contact

Susan Fargo
[email protected]
708-216-8046
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients ≥ 18 years old
Patients undergoing shoulder arthroscopy
Patients willing to participate and sign informed consent

Exclusion

Severe COPD/other contraindication to general anesthesia
Patient with a weight of less than 60 kg
Dementia, not alert or oriented to person, place, or time
Chronic pain patient with daily opioid use at home.
Patient with allergy to local anesthetics
Patient refusal
Total shoulder arthroplasty
Concomitant pain in different area from operative site.
Pregnancy
Patient with active infection on the injection sites for the blocks
Patients unable or willing to understand or comply with the study protocol

What this trial measures

  • Morphine requirement post surgery24 hours

    To compare the morphine equivalents administered in the first 24 hours after arrival in the recovery area between the two groups.